Recombinant Cynomolgus B2M Protein (Fc Tag)
Beta LifeScience
SKU/CAT #: BL-0221NP
Recombinant Cynomolgus B2M Protein (Fc Tag)
Beta LifeScience
SKU/CAT #: BL-0221NP
Catalog No.: BL-0221NP
Product Overview
| Tag | Fc |
| Host Species | Cynomolgus |
| Accession | Q8SPW0 |
| Synonym | B2M Beta-2-Microglobulin; B2M |
| Background | beta-2-Microglobulin (B2M) is a secreted protein with 1 Ig-like C1-type (immunoglobulin-like) domain which belongs to the beta-2-microglobulin family. B2M component of major histocompatibility complex (MHC) class I molecules, involved in the presentation of peptide antigens to the immune system. Polymers of beta 2-microglobulin can be found in tissues from patients on long-term hemodialysis. B2M is a protein found on the surface of many cells and plentiful on the surface of white blood cells. Serum B2M concentration is increased in renal diseases, various malignant diseases and some inflammatory and autoimmune disorders. B2M may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. B2M has been shown as a marker for monitoring inflammatory disease activity and it appears likely to have a destructive role in amyloidosis-related arthritis. B2M might be involved in the OA (osteoarthritis) pathogenesis. Defects in B2M are the cause of hypercatabolic hypoproteinemia. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation. B2M could be a potential therapeutic target in ovarian cancer. |
| Description | Recombinant Cynomolgus monkey Beta-2-microglobulin is expressed by our Mammalian expression system and the target gene encoding Ile21-Met119 is expressed with a Fc tag at the C-terminus. |
| Source | Human Cells |
| AA Sequence | Ile21-Met119 |
| Purity | >95% as determined by reducing SDS-PAGE. |
| Endotoxin | <0.1 ng/µg (1 EU/µg) as determined by LAL test. |
| Formulation | Recombinant Cynomolgus B2M Protein was lyophilized from a 0.2 μm filtered solution of PBS,pH7.4. |
| Reconstitution | Dissolve the lyophilized protein in distilled water. |
| Usage | For Research Use Only |
| Storage | Cynomolgus B2M protein should be stored at < -20°C, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7°C for 2-7 days.Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
