Native Human IgG Protein

Name: Native Human IgG Protein
Brand: Beta LifeScience
SKU: BLA-11784P
Availability: InStock

Collections: All products, High-quality recombinant proteins, Other recombinant proteins

Our products are highly customizable to meet your specific needs. You can choose options such as endotoxin removal, liquid or lyophilized forms, preferred tags, and the desired functional sequence range for proteins. Submitting a written inquiry expedites the quoting process.

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Product Overview

Accession	P01857
Synonym	FLJ39988 FLJ40036 FLJ40253 FLJ40587 FLJ40789 FLJ40834 G1m marker G2m marker G3m marker G4m marker HDC Heavy chain disease protein Human immunglobulin G Ig gamma 1 chain C region Ig gamma 2 chain C region Ig gamma 3 chain C region Ig gamma 4 chain C region IgG heavy chain locus IGHG 1 IGHG 2 IGHG 3 IGHG 4 IGHG1 IGHG2 IGHG3 IGHG4 Immunoglobulin Gm1 Immunoglobulin Gm3 Immunoglobulin Gm4 Immunoglobulin heavy constant gamma 1 immunoglobulin heavy constant gamma 1 (G1m marker) Immunoglobulin heavy constant gamma 2 immunoglobulin heavy constant gamma 2 (G2m marker) Immunoglobulin heavy constant gamma 3 immunoglobulin heavy constant gamma 3 (G3m marker) Immunoglobulin heavy constant gamma 4 immunoglobulin heavy constant gamma 4 (G4m marker) MGC117419 MGC45809
Description	Native Human IgG Protein is native.. It is a Full length protein
Source	Native
Purity	96% .IgA and IgM levels are <1% of the total IgG content by RID.
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Formulation	Lyophilised
Stability	The recombinant protein samples are stable for up to 12 months at -80°C
Reconstitution	See related COA
Unit Definition	For Research Use Only
Storage Buffer	Shipped at 4°C. Store at 4°C prior to reconstitution. Store at -80°C.

Target Details

Target Function	Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens. The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen.
Subcellular Location	Secreted. Cell membrane.
Database References	HGNC: 5525 OMIM: 147100 UniGene: Hs.510635
Associated Diseases	Multiple myeloma (MM)

FAQs

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Proteins are sensitive to heat, and freeze-drying can preserve the activity of the majority of proteins. It improves protein stability, extends storage time, and reduces shipping costs. However, freeze-drying can also lead to the loss of the active portion of the protein and cause aggregation and denaturation issues. Nonetheless, these adverse effects can be minimized by incorporating protective agents such as stabilizers, additives, and excipients, and by carefully controlling various lyophilization conditions.

Commonly used protectant include saccharides, polyols, polymers, surfactants, some proteins and amino acids etc. We usually add 8% (mass ratio by volume) of trehalose and mannitol as lyoprotectant. Trehalose can significantly prevent the alter of the protein secondary structure, the extension and aggregation of proteins during freeze-drying process; mannitol is also a universal applied protectant and fillers, which can reduce the aggregation of certain proteins after lyophilization.

Our protein products do not contain carrier protein or other additives (such as bovine serum albumin (BSA), human serum albumin (HSA) and sucrose, etc., and when lyophilized with the solution with the lowest salt content, they often cannot form A white grid structure, but a small amount of protein is deposited in the tube during the freeze-drying process, forming a thin or invisible transparent protein layer.

Reminder: Before opening the tube cap, we recommend that you quickly centrifuge for 20-30 seconds in a small centrifuge, so that the protein attached to the tube cap or the tube wall can be aggregated at the bottom of the tube. Our quality control procedures ensure that each tube contains the correct amount of protein, and although sometimes you can't see the protein powder, the amount of protein in the tube is still very precise.

To learn more about how to properly dissolve the lyophilized recombinant protein, please visit Lyophilization FAQs.