Native Human Alpha 1 Acid Glycoprotein

Name: Native Human Alpha 1 Acid Glycoprotein
Brand: Beta LifeScience
SKU: BAR-0061P
Price: 180.0 USD
Availability: InStock

Collections: All products, Native proteins

Price

Size

1mg

Quantity

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Product Overview

Description	Native Human Alpha-1-Acid Glycoprotein (AGP; Orosomucoid) functions as a key acute-phase reactant with multifaceted roles in drug binding, immunomodulation, and maintenance of capillary barrier integrity. This highly glycosylated sialoprotein, primarily synthesized in hepatocytes, demonstrates characteristic rapid elevation during inflammatory states and operates through its capacity to bind numerous basic and neutral drugs within its central calyx structure, thereby significantly altering drug distribution, bioavailability, and clearance patterns while simultaneously modulating immune responses through inhibition of neutrophil activation and platelet aggregation. The protein's dynamic glycosylation patterns and genetic polymorphisms across its various isoforms further refine its interactions with therapeutic compounds and immune cells, making it an essential factor in pharmacokinetic modeling, therapeutic drug monitoring, and investigating the pathophysiology of inflammatory diseases, cancer progression, and cardiovascular disorders where its plasma concentration serves as a sensitive biomarker of inflammatory burden.
Source	Human Plasma
Form	Lyophilized Powder
Buffer	Lyophilized from deionized water
Purity	Greater than 95% as determined by SDS-PAGE.
Molecular Weight	45kDa
Protein Determination	Extinction Coefficient (E) = 0.89 (0.1% at 280 nm, 1 cm pathway)
Storage/Handling	≤ -20 °C

FAQs

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Proteins are sensitive to heat, and freeze-drying can preserve the activity of the majority of proteins. It improves protein stability, extends storage time, and reduces shipping costs. However, freeze-drying can also lead to the loss of the active portion of the protein and cause aggregation and denaturation issues. Nonetheless, these adverse effects can be minimized by incorporating protective agents such as stabilizers, additives, and excipients, and by carefully controlling various lyophilization conditions.

Commonly used protectant include saccharides, polyols, polymers, surfactants, some proteins and amino acids etc. We usually add 8% (mass ratio by volume) of trehalose and mannitol as lyoprotectant. Trehalose can significantly prevent the alter of the protein secondary structure, the extension and aggregation of proteins during freeze-drying process; mannitol is also a universal applied protectant and fillers, which can reduce the aggregation of certain proteins after lyophilization.

Our protein products do not contain carrier protein or other additives (such as bovine serum albumin (BSA), human serum albumin (HSA) and sucrose, etc., and when lyophilized with the solution with the lowest salt content, they often cannot form A white grid structure, but a small amount of protein is deposited in the tube during the freeze-drying process, forming a thin or invisible transparent protein layer.

Reminder: Before opening the tube cap, we recommend that you quickly centrifuge for 20-30 seconds in a small centrifuge, so that the protein attached to the tube cap or the tube wall can be aggregated at the bottom of the tube. Our quality control procedures ensure that each tube contains the correct amount of protein, and although sometimes you can't see the protein powder, the amount of protein in the tube is still very precise.

To learn more about how to properly dissolve the lyophilized recombinant protein, please visit Lyophilization FAQs.