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Recombinant Interleukin-2 (IL-2) Proteins
23 products
Recombinant human IL-2 plays a pivotal role in modern immunology and biomedical research. Known for its influence on immune cell regulation and activation, this powerful cytokine supports critical research in cancer immunotherapy, autoimmune conditions, and vaccine development. At Beta LifeScience, our selection of high-quality recombinant IL-2 proteins is engineered for consistency, purity, and exceptional bioactivity—helping researchers advance discovery with confidence.
From T-cell proliferation studies to immune response modulation, these recombinant proteins are an essential component in labs around the world. Whether you're exploring therapeutic mechanisms or designing new immunotherapies, our recombinant human IL-2 products offer reliable performance across a range of experimental conditions.
What Is Interleukin-2?
Interleukin-2 (IL-2) is a glycoprotein primarily secreted by activated CD4+ and CD8+ T lymphocytes. It serves as a central regulator in immune responses, initiating the expansion and differentiation of various immune cells—including T cells, B cells, and natural killer (NK) cells. IL-2 interacts with its receptor complex (IL-2R) composed of three subunits (α, β, and γ), which together trigger downstream pathways critical for immune activation.
This complex signaling cascade promotes T-cell growth, enhances cytotoxic activity, and contributes to immune homeostasis. IL-2 has been extensively studied for its therapeutic potential, especially in oncology and infectious disease research.
Applications of Recombinant Human IL-2
Recombinant human IL-2 proteins are widely used in experimental and clinical applications. These include:
- Cancer Immunotherapy: IL-2 promotes expansion of cytotoxic T lymphocytes and NK cells that target tumor cells. Recombinant interleukin 2 is often studied for its synergy with checkpoint inhibitors and CAR-T therapies.
- Autoimmune Disease Research: Investigating how IL-2 regulates T regulatory (Treg) cells helps in understanding conditions like rheumatoid arthritis or lupus.
- Vaccine Development: Interleukin 2 human recombinant is a valuable adjuvant in vaccine research, enhancing the host immune response.
- Cell Culture and Expansion: Recombinant human interleukin 2 supports in vitro culture systems for T-cell expansion and functional assays.
- Transplantation Studies: It plays a role in immune tolerance mechanisms and has applications in graft-versus-host disease models.
By delivering consistent performance, our human recombinant IL-2 proteins help researchers uncover deeper insights into immune signaling and therapy development.
Why Choose Beta LifeScience IL-2 Proteins?
We offer a diverse range of recombinant IL-2 proteins tailored for research precision and performance. Our IL-2 products are expressed in multiple systems—E. coli, mammalian cells, yeast—to meet different study requirements. Here’s what sets our collection apart:
- Validated Activity: Every recombinant human IL-2 protein is tested via SDS-PAGE and functional bioassays, such as cell proliferation or receptor binding.
- High Purity: Our purification standards ensure over 95% purity for most IL-2 variants, ideal for sensitive and reproducible experiments.
- Multiple Formats: Available in active, GMP-grade, His-tagged, GST-fused, and biotinylated versions to suit custom workflows.
- Broad Species Coverage: We provide interleukin-2 proteins not just for humans but also for mice, rabbits, rats, and other species to support comparative immunology.
Whether you're working on basic research or translational science, our recombinant interleukin-2 proteins ensure consistency and reliability in every lot.
Resources
Explore Our Human Recombinant IL-2 Selection
Our catalog includes both wild-type and mutant forms of recombinant human IL-2, available with or without purification tags, at varying expression levels and host systems. Whether you need IL-2 for ELISA development, cell therapy research, or in vivo models, we have a product that fits.
All IL-2 proteins are delivered lyophilized or in solution, ready for immediate use. Custom bulk orders and formulation requests are also welcome.
Featured Products
| Cat. No. | Species | Product Description | Host | Structure | Purity | Activity | Features |
|---|---|---|---|---|---|---|---|
| BLC-05337P | Human | Human IL-2 Protein, Active | E.coli | P60568 (21-153aa) | > 95% | ≥1×10^7 IU/mg | SDS-PAGE, Cell Based Assay |
| BLC-05319P | Human | Human IL-2 Protein, Active | Mammalian cell | P60568 21-153aa (L80F & R81D & L85V & I86V & I92F) | > 95% | ED50: 0.5 ng/mL | SDS-PAGE, Cell Based Assay |
| BLC-10775P | Human | Human IL-2 Protein (GST) | E.coli | P60568 (21-153aa) | > 90% | Testing in Progress | SDS-PAGE |
| BLC-05416P | Human | Human IL-2 Protein, Active, GMP | E.Coli | P60568 (21-153aa) | > 98% | > 1.0 × 107 IU/mg | SDS-PAGE, Cell Based Assay |
| BLC-03457P | Human | Human IL-2 Protein (His) | E.coli | P60568 (21-153aa) | > 85% | Testing in Progress | SDS-PAGE |
| BLC-03039P | Human | Human IL-2 Protein (His) | Yeast | P60568 (21-153aa) | > 90% | Testing in Progress | SDS-PAGE |
| BLC-05429P | Human | Human IL-2 Protein (His), Active | Mammalian cell | P60568 (21-153aa) | > 95% | ED50: 0.5 ng/mL | SDS-PAGE, Cell Based Assay |
| Human | Human IL-2 Protein, Active | Mammalian cell | P60568 (21-153aa) | > 95% | ≥ 1 x 107 IU/mg | SDS-PAGE, Cell Based Assay | |
| BL-1714NP | Human | Human IL-2 Protein | E.coli | P60568 (21-153aa) | > 95% | ≥1×107 IU/mg | SDS-PAGE, Cell Based Assay, BLI |
| BL-2899NP | Human | Human IL-2 Superkine Protein (Mutant, C-6His) | Mammalian cell | P60568 21-153aa (L100F, R101D, L105V, I106V, I112F) | > 95% | ED50: 151.39 pg/mL | SDS-PAGE, Cell Based Assay, BLI |
| BL-2730NP | Human | Biotinylated Human IL-2 Protein (C-6His-Avi) | Mammalian cell | P60568 (21-153aa) | > 90% | ED50: 0.2 ng/mL | SDS-PAGE, Cell Based Assay, BLI, ELISA |
| BL-2127NP | Human | Human IL-2 Protein (C-6His) | Mammalian cell | P60568 (21-153aa) | > 95% | ≥1×107 IU/mg | SDS-PAGE, Cell Based Assay, BLI |
| BL-2887NP | Human | Human IL-2 Protein (aldesleukin) | E.coli | P60568 (22-153aa) | > 95% | ED50: 90-270 pg/mL | SDS-PAGE, Cell Based Assay, BLI |
| BLC-02916P | Rhesus macaque | Rhesus Macaque IL-2 Protein (His-SUMO&Myc) | E.coli | P68291 (21-154aa) | > 90% | Testing in Progress | SDS-PAGE |
| BLPSN-2803 | Canine | Canine IL-2 Protein (147 Cys/Ser) | E.coli | Q29416 (21-155aa,147Cys/Ser) | > 95% | Binds rh-IL2Ra-Fc at b/t 0.3125-20 μg/mL | SDS-PAGE, ELISA |
| BLC-06764P | Llama | Lama Glama IL-2 Protein (His) | Yeast | Q865X2 (21-154aa) | > 90% | Testing in Progress | SDS-PAGE |
| BLC-06596P | Llama | Lama Glama IL-2 Protein (His) | E.coli | Q865X2 (21-154aa) | > 90% | Testing in Progress | SDS-PAGE |
| BLC-00201P | Golden hamster | Mesocricetus Auratus IL-2 Protein (His&StrepII) | E.coli | B3VBJ5 (21-155aa) | > 90% | Testing in Progress | SDS-PAGE |
| BLC-05311P | Mouse | Mouse IL-2 Protein, Active | E.coli | P04351 (21-169aa) | > 95% | ED50: < 0.5 ng/mL. | SDS-PAGE, Cell Based Assay |
| BLPSN-2805 | Mouse | Mouse IL-2 Protein | E.coli | P04351 (21-169aa) | > 92% | ED50: 6-30 ng/mL. | SDS-PAGE, Cell Based Assay, ELISA |
| BLC-11012P | Rabbit | Rabbit IL-2 Protein (His) | Yeast | O77620 ( 21-153aa) | > 85% | Testing in Progress | SDS-PAGE |
| BLC-04118P | Rabbit | Rabbit IL-2 Protein (His) | E.coli | O77620 ( 21-153aa) | > 90% | Testing in Progress | SDS-PAGE |
| BLPSN-2806 | Rat | Rat IL-2 Protein | E.coli | P17108 (21-155aa) | > 95% | ED50: 0.5-3 ng/mL | SDS-PAGE, Cell Based Assay, ELISA |
IL-2 Variants for Specialized Applications
Not all IL-2 proteins are created equal. Some projects require specialized forms of human recombinant IL-2, including engineered mutants for enhanced stability, reduced toxicity, or altered receptor binding profiles.
- IL-2 Superkines: Modified IL-2 variants with higher affinity to IL-2 receptor βγ chains. Useful in cancer therapy where strong immune stimulation is needed without Treg activation.
- Biotinylated IL-2: Ideal for high-sensitivity ELISA, BLI, or SPR applications where precise quantification and receptor interaction studies are required.
- GMP-grade IL-2: Suitable for preclinical or regulated environments, providing strict quality control and traceability.
Beta LifeScience offers all these options under one roof to streamline your research and support next-generation immunotherapies.
Optimized Expression and Tagging Options
We understand that research needs vary. That’s why our recombinant human interleukin 2 proteins are available in multiple formats:
- His-Tagged IL-2: Great for easy purification and detection.
- GST-Tagged IL-2: Useful for solubility and improved folding.
- Tag-Free IL-2: Ideal for sensitive functional studies without structural alterations.
- Mammalian Expressed IL-2: Preserves proper folding and post-translational modifications essential for full bioactivity.
- E. coli and Yeast Expressed IL-2: Cost-effective solutions for screening and in vitro studies.
No matter your system or target application, we offer a version of interleukin 2 human recombinant to suit your workflow and budget.
Quality You Can Trust
At Beta LifeScience, we are committed to delivering proteins that meet the highest standards in life science research:
- Endotoxin-Free: Our recombinant IL-2 proteins are endotoxin-tested to ensure clean results, especially for in vivo use.
- Reproducible Batch Quality: Every lot is tested to confirm structural integrity and functional performance, so your data stays consistent.
- Fast Turnaround & Global Delivery: We ship to research labs worldwide, with rapid delivery and responsive customer support.
Each IL-2 protein we produce is backed by detailed datasheets and technical documentation to support your experimental planning.
Final Thoughts
Recombinant human IL-2 is more than just a research reagent—it's a cornerstone of immunological discovery. Its ability to modulate and amplify immune responses makes it a powerful tool in both basic and applied science. At Beta LifeScience, we help researchers accelerate progress with expertly crafted IL-2 proteins designed for accuracy, purity, and biological relevance.
Explore our growing collection of recombinant human interleukin 2 proteins today and experience the Beta LifeScience difference in your lab.
FAQs
What is recombinant human IL-2 used for?
Recombinant human IL-2 is widely used in immunotherapy research, especially for boosting immune cell activity against infections, tumors, and autoimmune diseases.
What is the difference between IL-2 and recombinant IL-2?
IL-2 is a natural cytokine made by immune cells, while recombinant IL-2 is a lab-produced version used in controlled experiments and therapeutic development.
Is your recombinant human interleukin 2 biologically active?
Yes, many of our recombinant human IL-2 proteins are biologically active and tested using SDS-PAGE and cell-based assays for functionality.
How do I choose the right IL-2 protein for my research?
Consider the host cell (e.g., E. coli, mammalian), protein tag (His, GST, etc.), and intended application. Our product descriptions list activity levels and purity to help guide your decision.
Can I use these IL-2 proteins for clinical applications?
We offer GMP-grade recombinant IL-2 proteins that are suitable for translational and preclinical studies. Always verify regulatory requirements for clinical use.
