Recombinant Hepatocyte Growth Factor (HGF) Proteins
6 products
Hepatocyte Growth Factor (HGF) is a powerful protein known for its regenerative capabilities. It plays a central role in tissue development, repair, and cellular signaling, making it a key focus in life science research and drug development. At Beta LifeScience, our collection of recombinant HGF proteins is tailored for high-performance applications, including cancer biology, regenerative medicine, and signaling pathway studies.
HGF proteins are widely used to investigate how cells grow, migrate, and survive under various conditions. Whether you’re working on wound healing models or targeting the HGF/c-Met pathway in oncology, we provide reliable, active forms of HGF across multiple species—including human, mouse, rat, bovine, canine, and cynomolgus—to meet your experimental needs.
What Is Hepatocyte Growth Factor?
Originally discovered as a mitogen for hepatocytes, HGF is now recognized as a pleiotropic factor that affects a wide array of biological systems. It exerts its effects through the c-Met receptor, a tyrosine kinase involved in signal transduction pathways that regulate proliferation, motility, morphogenesis, and angiogenesis.
This receptor-ligand pair is essential for embryonic development and post-injury tissue regeneration. Beyond normal physiological roles, aberrant HGF/c-Met signaling is linked to cancer progression, fibrosis, and inflammatory conditions. As such, HGF has become a target of interest in therapeutic development and a tool for understanding cell behavior in disease states.
In tissue repair, HGF is known to promote epithelial and endothelial regeneration, making it a key candidate in studies focused on wound healing, organ injury recovery, and even stem cell therapy. In cancer biology, it helps researchers understand how tumors invade surrounding tissue and establish new vasculature.
Why Researchers Choose Recombinant HGF Proteins?
The use of recombinant HGF proteins in research ensures control over purity, activity, and consistency across batches. Unlike natural sources, recombinant production allows researchers to work with biologically active proteins free from contamination or degradation.
At Beta LifeScience, our recombinant HGF proteins are produced using mammalian expression systems, which maintain proper protein folding and post-translational modifications. Each product is validated through rigorous bioassays and quality control steps such as SDS-PAGE, HPLC, and ED50 testing. This results in proteins with high specific activity and reproducible performance.
Researchers trust our recombinant proteins for their ability to deliver clear, consistent results—whether it's activating cell signaling pathways, inducing proliferation, or analyzing protein-receptor interactions.
Resources
Hepatocyte Growth Factor (HGF) Blog Articles
Resolving HGF and HGFR: The Tystery of Hepatocyte Growth Factor and its Receptor
Featured Products
| Cat. No. | Species | Product Description | Host | Structure | Purity | Activity | Features |
|---|---|---|---|---|---|---|---|
| BLC-05961P | Human | Human HGF Protein (His), Active | Mammalian cell | P14210 (32-728aa) | ≥ 95 % | ED50: ≤10 ng/ml. | SDS-PAGE |
| BL-0311NP | Human | Human HGF Protein (C-6His), Active | Mammalian cell | P14210 (32-728aa) | ≥ 95 % | ED50: 0.3-1.5 ng/ml. | SDS-PAGE,Cell Based,HPLC,BLI |
| BLPSN-2428 | Human | Human HGF Protein, Active | Mammalian cell | P14210 (1-728aa) | ≥ 95 % | ED50: 0.2-2 ng/mL. | SDS-PAGE,Cell Based |
| Human | Human HGF Protein, Active | Mammalian cell | P14210 (32-728aa) | ≥ 90 % | ED50: ≤20 ng/mL. | SDS-PAGE,Cell Based | |
| BL-1219NP | Mouse | Mouse HGF Protein (C-6His) | Mammalian cell | Q08048 (33-728aa) | ≥ 95 % | Not Test | SDS-PAGE |
| BLPSN-2430 | Mouse | Mouse HGF Protein (His Tag), Active | Mammalian cell | Q08048 (1-728aa) | > 70 % | ED50: 1-8 ng/mL. | SDS-PAGE |
| BLPSN-2429 | Mouse | Mouse HGF Protein, Active | Mammalian cell | Q08048 (1-728aa) | ≥ 95 % | ED50: 1-4 ng/ml. | SDS-PAGE,Cell Based |
| BLPSN-2431 | Rat | Rat HGF Protein, Active | Mammalian cell | P17945 (1-728aa) | ≥ 85 % | ED50: 1-6 ng/mL. | SDS-PAGE,Cell Based |
| BLC-02340P | Rat | Rat HGF Protein (GST) | E.coli | P17945 (477-728aa) | ≥ 90 % | Not Test | SDS-PAGE |
| BLC-00450P | Bovine | Bovine HGF Protein (His) | E.coli | Q76BS1 (32-494aa) | ≥ 85 % | Not Test | SDS-PAGE |
| BLC-07251P | Bovine | Bovine HGF Protein (His) | E.coli | Q76BS1 (32-494aa) | ≥ 85 % | Not Test | SDS-PAGE |
| BLPSN-2427 | Cynomolgus | Cynomolgus HGF Protein, Active | Mammalian cell | C9E9X5 (1-728aa) | ≥ 95 % | ED50: 2-10 ng/mL. | SDS-PAGE,Cell Based |
| BLPSN-2426 | Canine | Canine HGF Protein, Active | Mammalian cell | Q867B7 (1-730aa) | ≥ 95 % | ED50: 1-4 ng/mL. | SDS-PAGE,Cell Based |
Key Applications of HGF Proteins
Our recombinant HGF proteins support a wide range of research and development fields:
- Cancer Research: Analyze the role of HGF/c-Met in tumor growth, metastasis, and resistance to therapies. These proteins are often used in drug screening and pathway inhibition studies.
- Regenerative Medicine: Explore the regenerative potential of HGF in wound healing, organ repair, and stem cell therapies. HGF promotes cell migration and proliferation in damaged tissues.
- Fibrosis Studies: Understand how HGF modulates fibrosis in the liver, kidneys, and lungs. It acts as an anti-fibrotic agent by balancing tissue remodeling.
- Developmental Biology: Investigate how HGF influences embryonic tissue morphogenesis and organogenesis.
- Angiogenesis and Vascular Biology: Use HGF to assess new blood vessel formation and its role in ischemic diseases or tumor vascularization.
Looking for more growth factors? Explore our Recombinant FGF Proteins and Recombinant VEGF Proteins collections for related applications.
Consistency and Quality You Can Trust
At Beta LifeScience, we prioritize scientific precision. Our HGF proteins go through a series of validation tests to confirm their purity and functionality:
- Purity Levels: Proteins are available at ≥85% or ≥95% purity depending on the application. Verified by SDS-PAGE and HPLC to ensure minimal contaminants or degradation products.
- Biological Activity: Tested through cell-based assays measuring cellular proliferation or signaling activation. ED50 values are included on every datasheet to help you plan accurate dose-response experiments.
- Tag Options and Formats: Our catalog includes His-tagged and full-length versions of HGF for flexibility in purification, labeling, or direct use in assays. Various expression systems—such as mammalian or E. coli—allow researchers to match format with their project’s goals and budget.
- Species Specificity: Human, mouse, rat, bovine, canine, and cynomolgus monkey versions are available, making cross-species research straightforward.
Every product comes with a downloadable Certificate of Analysis (COA), providing transparency into protein validation and performance metrics. This lets you move from planning to execution with confidence.
Supporting Your Workflow
We understand that different research setups require different specifications. Whether you need small-scale formats for pilot studies or large quantities for commercial development, we offer flexible packaging and custom production services.
Our technical support team can also help you select the right HGF protein based on your assay type, host system preferences, or species specificity. If you're working on long-term studies, we can provide bulk quotes or reserve inventory to support consistency across your project’s lifecycle.
Interested in scaling up your study with additional factors? Our Growth Factor Protein Collection includes dozens of highly active cytokines and signaling molecules compatible with your HGF-based research.
Power Your Research with Proven HGF Proteins
Beta LifeScience is committed to delivering scientifically validated tools that move research forward. Our recombinant HGF proteins are developed to match the precision and reliability researchers demand, whether you're analyzing cell behavior, testing new therapeutics, or exploring complex biological systems.
With optimized purity, consistent bioactivity, and trusted manufacturing protocols, our HGF proteins can help you uncover the insights that matter. Browse our catalog today or reach out for assistance in identifying the right product for your needs. Let’s accelerate your discoveries—together.
