95 products
Hemagglutinin (HA) is the major surface glycoprotein of the influenza virus, responsible for receptor binding and membrane fusion during viral entry. It is the primary antigenic target of neutralizing antibodies and a critical component of seasonal and pandemic influenza vaccines. As a class I viral fusion protein, HA mediates attachment to sialic acid-containing receptors on host cells and promotes endosomal membrane fusion, making it essential for infectivity and a key target for antiviral and vaccine research.
Influenza HA is a homotrimeric transmembrane protein expressed on the virion surface. It is synthesized as a single polypeptide precursor (HA0) and cleaved into HA1 and HA2 subunits by host proteases, a step required for infectivity. HA plays multiple roles in the viral life cycle:
HA undergoes continuous antigenic drift (point mutations) and occasional shift (reassortment), driving seasonal epidemics and pandemic threats. This diversity makes HA subtype selection (e.g., H1, H3, H5, H7) a critical experimental consideration.
Target Name: Hemagglutinin (HA)
Synonyms: A, HA0, HA1 subunit, HA2 subunit, viral surface glycoprotein
UniProt ID (example, H1N1 A/California/04/2009): C3W5S2
Target Class: Viral envelope glycoprotein; class I fusion protein; major antigen
Recombinant HA is widely used in vaccine development, serology, and antiviral studies rather than receptor-style signaling workflows.
Recombinant HA proteins are most effective in functional and immunoassay workflows:
Because HA is a viral surface antigen and fusion protein, it is not suitable for intracellular enzyme studies such as methylation or phosphorylation assays. It is best suited for serology, vaccine research, antibody characterization, receptor binding, and viral entry-related workflows.
Submit an inquiry or email inquiry@betalifesci.com for a customization request or bulk order quote.
Fast turnaround production is available at a affordable price point if none of our catalog products fits your desire specifications.
Selecting the right HA protein depends on your assay objectives: subtype matching, trimer integrity, tag preference, and expression system. Aligning these factors ensures reliable binding data and reproducible immunological results.
Selection depends on your experimental goal:
Custom HA constructs are often justified when:
If your project involves vaccine evaluation, serosurveillance, antibody discovery, receptor binding analysis, or fusion inhibition studies, selecting the right HA subtype, strain, format, and expression system is essential for reliable results.
We can help you:
Submit your project details for expert evaluation. Our technical team will review your application and recommend the most suitable influenza HA protein format for your research.
Qualified projects may be eligible for discounted or free samples for validation.
Subscribe today for the latest news and special offers.
