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Interleukin-6 receptor alpha (IL6RA) is a key cytokine receptor involved in immune regulation and inflammation. It exists in membrane-bound and soluble forms, enabling both classical and trans-signaling pathways. Upon binding IL-6, IL6RA associates with gp130 to activate downstream pathways such as JAK/STAT, MAPK, and PI3K. Dysregulated IL6RA signaling is linked to autoimmune diseases, chronic inflammation, and cancer, making it an important therapeutic target.
IL6RA is a type I membrane protein that binds IL-6 and forms a signaling complex with gp130. It is involved in:
In classical signaling, IL-6 binds membrane IL6RA, while soluble IL6RA enables signaling in cells lacking the receptor, expanding IL-6 responsiveness.
Target Name: IL6RA
Synonyms: IL-6 receptor; CD126
UniProt ID: P08887
Target Class: Cytokine receptor
IL6RA mediates IL-6 signaling through two modes: classical signaling via membrane-bound IL6RA and trans-signaling via soluble IL6RA, both requiring gp130 to initiate downstream pathways. Upon activation, JAK/STAT, MAPK, and PI3K/AKT cascades are triggered, leading to gene transcription that regulates inflammation, cell survival, and proliferation. These signaling events are tightly controlled by regulatory proteins such as SOCS and ADAM17, and can be therapeutically targeted by anti-IL6R antibodies to modulate immune and inflammatory responses.
IL6RA is widely used in studies focused on cytokine biology and immune regulation.
Because IL6RA is a receptor, it is best suited for cell-based and binding assays, rather than enzymatic activity studies.
Submit an inquiry or email inquiry@betalifesci.com for a customization request or bulk order quote.
Fast turnaround production is available at a affordable price point if none of our catalog products fits your desire specifications.
Selection depends on membrane vs soluble forms, as well as the biological context of the study. Proper selection ensures accurate representation of IL-6 signaling dynamics and improves reproducibility.
Custom constructs are often necessary when:
If your project involves IL-6 binding studies, classical or trans-signaling assays, inflammation research, therapeutic antibody development, or JAK/STAT pathway analysis, selecting the right IL6RA protein format is essential for reliable and reproducible results.
We can help you:
Submit your project details for expert evaluation. Our technical team will review your application and recommend the most suitable IL6RA protein format for your research.
Qualified projects may be eligible for discounted or free samples for validation.
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