Recombinant Mouse EDAR Protein (Fc Tag)

Beta LifeScience SKU/CAT #: BL-0118NP
Recombinant Mouse EDAR Protein (Fc Tag)

Recombinant Mouse EDAR Protein (Fc Tag)

Beta LifeScience SKU/CAT #: BL-0118NP
Catalog No.: BL-0118NP

Product Overview

Tag Fc
Host Species Mouse
Accession Q9R187
Synonym EDAR Tumor necrosis factor receptor superfamily member EDAR; Anhidrotic ectodysplasin receptor 1; Downless; Ectodermal dysplasia receptor; Ectodysplasin-A receptor
Background Ectodysplasin A receptor (EDAR) is a type I transmembrane protein of the TNF-alpha receptor superfamily which plays a key role in ectodermal differentiation. EDAR was encoded by the mouse downless gene and defective in human dominant and recessive forms of autosomal hypohidrotic ectodermal dysplasia (EDA) syndrome. The extracellular domain of EDAR contains 14 cysteine residues, six of which approximate the TNFRSF cysteine-rich region, the cytoplasmic domain contains a region with homology to the death domains found in other TNFRSF members. EDAR has been suggested to be an early and important promoter of placode development in all ectodermal organs, such as uch as hair follicles, teeth and sweat glands. EDA-A1, the A1 isoform of EDA, is the EDAR ligand. EDA and EDA are implicated in appendage development by the cloning of a gene underlying hypohidrotic ectodermal dysplasia (HED) in mouse and human. HED is characterized by agenesis or malformation of ectoderm-derived appendages, such as teeth, sweat glands and hair follicles, while the skin itself develops normally.
Description Recombinant Mouse Ectodysplasin Receptor is expressed by our Mammalian expression system and the target gene encoding Glu27-Ile189 is expressed with a Fc tag at the C-terminus.
Source Human Cells
AA Sequence Glu27-Ile189
Purity >95% as determined by reducing SDS-PAGE.
Endotoxin <0.1 ng/µg (1 EU/µg) as determined by LAL test.
Formulation Recombinant Mouse EDAR Protein was lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Reconstitution Dissolve the lyophilized protein in distilled water.
Usage For Research Use Only
Storage Mouse EDAR protein should be stored at < -20°C, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7°C for 2-7 days.Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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