Recombinant Cynomolgus OX40L Protein (Fc Tag)
Beta LifeScience
SKU/CAT #: BLPSN-3623
Recombinant Cynomolgus OX40L Protein (Fc Tag)
Beta LifeScience
SKU/CAT #: BLPSN-3623
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Product Overview
Tag | Fc |
Host Species | Cynomolgus |
Accession | F7FL80 |
Synonym | OX40L Tumor necrosis factor ligand 2B; TNFSF4; OX-40L |
Background | Tumor necrosis factor ligand superfamily member 4(TNFSF4/OX40L) is a single-pass type II membrane protein. OX40L is expressed by DCs, macrophages and B cells and signals via its cognate receptor OX40 which is mainly expressed on APCs. OX40L/OX40 interactions are important in T-cell activation and survival and for the generation of memory T cells from activated effector T cells. It is a cytokine that binds to TNFRSF4, Co-stimulates T-cell proliferation and cytokine production. OX40L/OX40 interactions are important in T-cell activation and survival and for the generation of memory T cells from activated effector T cells. |
Description | A DNA sequence encoding the cynomolgus TNFSF4 (F7FL80) (Gln51-Leu183) was produced with the Fc region of mouse IgG1 at the N-terminus. |
Source | HEK293 |
Predicted N Terminal | Asp |
AA Sequence | Gln51-Leu183 |
Molecular Weight | The recombinant cynomolgus TNFSF4 is a disulfide-linked homodimer. The reduced monomer comprises 369 amino acids and has a calculated molecular mass of 42 KDa.The apparent molecular mass of it is approximately 48 KDa respectively in SDS-PAGE. |
Purity | Greater than 85% as determined by SDS-PAGE |
Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method |
Bioactivity | Immobilized Cynomolgus mFc-TNFSF4 at 10 ug/ml (100 ul/well) can bind human TNFRSF4-Fch, The EC50 of human TNFRSF4-Fch is 0.23-0.55 ug/ml. |
Formulation | Lyophilized from sterile PBS, pH 7.4. |
Stability | Recombinnat Proteins are stable for up to 1 year from date of receipt at -70°C |
Usage | For Research Use Only |
Storage | Store recombinant protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |