Recombinant Cynomolgus NKp30 Protein (His Tag)
Beta LifeScience
SKU/CAT #: BLPSN-3521
Recombinant Cynomolgus NKp30 Protein (His Tag)
Beta LifeScience
SKU/CAT #: BLPSN-3521
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Product Overview
Tag | His |
Host Species | Cynomolgus |
Accession | XP_005553604.1 |
Synonym | NKp30 |
Background | Natural Cytotoxicity Triggering Receptor 3, NCR3, also known as NKp3, or CD337, is a natural cytotoxicity receptor, expressed on subsets of human peripheral blood NK cells, involved in NK cell killing of tumor cells and immature dendritic cells. The cellular ligand for NKp3 has remained elusive, but the membrane-associated heparan sulfate (HS) proteoglycans are involved in the recognition of cellular targets by NKp3 was recently reported. NKp3 is a member of the immunoglobulin superfamily and one of three existing natural cytotoxicity-triggering receptors. NKp3 is a glycosylated protein and is thought to be selectively expressed in resting and activated natural killer cells. NKp3 is a stimulatory receptor on human NK cells implicated in tumor immunity, and is capable of promoting or terminating dendritic cell maturation. NCR3 may play a role in inflammatory and infectious diseases. |
Description | A DNA sequence encoding the cynomolgus NCR3 (XP_005553604.1) (Met1-Gly135) was expressed with a His tag at the C-terminus. Cynomolgus and Rhesus NCR3 sequences are identical. |
Source | HEK293 |
Predicted N Terminal | Leu 19 |
AA Sequence | Met1-Gly135 |
Molecular Weight | The recombinant cynomolgus NCR3 consists of 128 a.a. and predicts a molecular mass of 14.3 kDa. |
Purity | >90 as determined by SDS-PAGE. |
Endotoxin | < 1.0 EU per μg protein as determined by the LAL method. |
Bioactivity | 1.Measured by its binding ability in a functional ELISA. 2.Immobilized cynomolgus NCR3-His at 10ug/mL (100uL/well) can bind cynomolgus NCR3LG1-Fc, the EC50 of cynomolgus NCR3LG1-Fc is 20-150ng/mL. |
Formulation | Lyophilized from sterile PBS, pH 7.4.. |
Stability | The recombinant proteins are stable for up to 1 year from date of receipt at -70°C. |
Usage | For Research Use Only |
Storage | Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |