Recombinant Stem Cell Factor (SCF) Proteins

Stem Cell Factor (SCF) is a crucial growth factor that guides how cells grow, divide, and stay alive. Whether you're studying blood cell production, stem cell survival, or early tissue development, SCF helps you replicate the natural conditions that cells need to thrive. At Beta LifeScience, we offer a wide selection of recombinant Stem Cell Factor proteins that are tested, active, and ready to support your most demanding experiments.

Our SCF proteins are available in human, mouse, and rat forms—expressed using multiple host systems for flexible use in cell-based research, assay development, or regenerative medicine workflows.

What is Stem Cell Factor?

Stem Cell Factor (SCF), also known as steel factor or KIT ligand, is a key signaling protein that binds to the c-Kit (CD117) receptor. This receptor is found on the surface of various cell types, particularly hematopoietic stem cells (HSCs), which develop into red and white blood cells.

When SCF binds to c-Kit, it triggers important cellular pathways like PI3K/Akt, MAPK, and JAK/STAT—each responsible for different aspects of growth, migration, and differentiation. This interaction influences many biological processes, including:

• Blood cell formation (hematopoiesis)
  
• Neuron growth and regeneration
  
• Reproductive cell development
  
• Tissue repair after injury
  
• Stem cell maintenance and proliferation
  

Without SCF, many of these systems wouldn’t function properly, making it a go-to protein in cell biology, disease modeling, and drug screening.

Benefits of Using Recombinant SCF

Getting large amounts of natural SCF from biological sources isn’t easy—and it’s often not practical for research or clinical applications. That’s where recombinant SCF makes a big difference. These lab-produced proteins are carefully engineered to mimic the structure and function of natural SCF, giving researchers a consistent and reliable way to study cell growth, survival, and regeneration.

Here’s why recombinant SCF is the go-to choice for researchers:

• High Purity & Activity: Each batch is thoroughly tested to ensure it meets strict quality standards for purity and biological function.
• Lot-to-Lot Consistency: You get the same reliable results every time, with no surprises between batches.
• Ready-to-Use Formats: Choose from multiple expression systems and tag formats to suit your experiment’s needs.
• Cost and Time Efficiency: Avoid the hassle and expense of purifying SCF from natural sources.
• Trusted in Stem Cell & Blood Research: Recombinant SCF is widely used in labs working on hematopoiesis, tissue repair, and cell-based therapies.

At Beta LifeScience, we produce SCF proteins using optimized hosts like E. coli, mammalian cells, and baculovirus systems—ensuring every product retains its native-like structure and performance. Whether you're focused on early-stage cell signaling or preclinical development, our SCF proteins help you work with precision and confidence.

Why Choose Beta LifeScience Recombinant SCF:

✅ High Purity Levels (≥ 90% to 95%)

✅ Active Forms Validated via ED50 Testing

✅ Species Variants for Human, Mouse, and Rat

✅ Multiple Tags including His, C-6His, and Biotinylated options

✅ Flexible Expression Systems (E. coli, mammalian cells, baculovirus)

✅ Optimized for Cell-Based Assays and ELISA platforms

We offer both full-length and truncated forms of SCF, allowing flexibility depending on your experiment’s requirements.

Applications of SCF Proteins in the Lab

Hematopoietic Stem Cell Culture

SCF is best known for its role in expanding and differentiating hematopoietic stem cells. In combination with IL-3, G-CSF, or GM-CSF, SCF supports in vitro blood cell development, mimicking the environment of bone marrow.

Neural Development and Repair

Research shows that SCF supports neuron survival, axonal growth, and regeneration of damaged nervous tissue. When used in neural cell models, SCF can promote recovery pathways similar to those seen in vivo.

Fertility and Germ Cell Research

During embryonic development, SCF controls the migration of germ cells to the gonads. It also plays a role in oocyte maturation and follicle survival. For researchers studying reproductive health, SCF is key to understanding early germline formation.

Stem Cell Expansion

Culturing stem cells in vitro can be challenging without the right microenvironment. SCF, along with bFGF, EGF, and LIF, creates the right signaling balance to keep stem cells healthy and undifferentiated.

Cancer Research and Drug Screening

Overexpression of c-Kit and SCF is linked to cancers like gastrointestinal stromal tumors (GIST), leukemia, and melanoma. Recombinant SCF is often used to study tumor cell behavior, signaling disruption, and the effects of drug candidates on SCF pathways.

Expression Systems That Fit Your Workflow

Each SCF protein is produced in a specific host system that aligns with your study needs:

• Mammalian cells: Best for high fidelity post-translational modifications
  
• Baculovirus: Suitable for eukaryotic expression with excellent yields
  
• E. coli: Cost-effective for high-purity protein in short timeframes
  

No matter your system, our proteins maintain native folding and biological activity, so you can trust your results.

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Resources

Featured Products

Cat. No.	Species	Product Description	Host	Structure	Purity	Activity	Features
BL-1670NP	Human	Human SCF Protein (C-6His), Active	Mammalian cell	P21583 (26-214aa)	≥ 95 %	ED50: 2-10 ng/ml	SDS-PAGE,Cell Based
BLPSN-4156	Human	Human SCF Protein (aa 1-189, His Tag), Active	Baculovirus	P21583 (1-189aa)	≥ 92 %	ED50: 1-5 ng/mL	SDS-PAGE,Cell Based,ELISA
BL-1699NP	Human	Human SCF Protein, Active	E.coli	P21583 (26-189aa)	≥ 95 %	ED50: 1-5 ng/mL	SDS-PAGE,Cell Based
	Human	Human SCF Protein, Active	Mammalian cell	P21583 (26-190aa)	> 90 %	ED50: 5-8 ng/mL	SDS-PAGE,Cell Based
BL-2249NP	Mouse	Mouse SCF Protein (C-6His)	Mammalian cell	P20826 (26-189aa)	≥ 95 %	Not Test	SDS-PAGE,HPLC
BLPSN-4157	Mouse	Mouse SCF Protein (His Tag), Active	Baculovirus	P20826 (1-189aa)	≥ 95 %	Linear range: 1.28-32 ng/ml.	SDS-PAGE,Cell Based,ELISA,HPLC
BLPSN-4158	Mouse	Mouse SCF Protein (His Tag), Biotinylated	Baculovirus	P20826 (1-189aa)	> 80 %	Not Test	SDS-PAGE
BL-1732NP	Mouse	Mouse SCF Protein, Active	E.coli	P20826 (26-189aa)	≥ 95 %	ED50: 4-12 ng/ml	SDS-PAGE,Cell Based
BL-2250NP	Rat	Rat SCF Protein (C-6His)	Mammalian cell	P21581 (26-189aa)	≥ 95 %	Not Test	SDS-PAGE
BL-0854NP	Rat	Rat SCF Protein (C-6His)	E.coli	P21581 (26-189aa)	≥ 95 %	Not Test	SDS-PAGE

Quality You Can Trust

Every SCF product from Beta LifeScience goes through a stringent quality control pipeline:

• Purity analysis with SDS-PAGE
• Biological validation using ED50 and cell-based assays
• Lot-to-lot consistency to ensure reproducible results
• Documentation with detailed COAs and protocols

Our team of scientists and product specialists is involved from design to final delivery, ensuring each product performs as promised.

Fast Shipping with No Surprises

Most of our recombinant SCF proteins are in stock, which means no delays or backorders. We ship fast across the US and offer fast international delivery as well.

Need bulk quantities or custom formulations? Reach out to us directly—we’ll get you exactly what you need.

Connect With Our Experts

Not sure which SCF protein is best for your project? We’re here to help. Whether you're comparing species, deciding between tags, or planning a multi-cytokine assay, our support team can walk you through the options.

→ Contact us for fast, expert assistance tailored to your research needs.

Accelerate Your Research with Beta LifeScience

Recombinant SCF proteins are essential for any lab studying cell signaling, stem cells, or regenerative biology. With our wide selection, validated activity, and fast shipping, you can keep your experiments moving forward—without downtime or doubts.

Browse our full range of Stem Cell Factor proteins today and give your research the support it deserves.