At Beta LifeScience, we pride ourselves on our deep understanding of the intricate world of proteins. Proteins, the building blocks of life, are not just simple molecules; they belong to intricate families and superfamilies that dictate their functions, structures, and interactions.
Protein Families: These are groups of proteins that share a common evolutionary origin. This shared lineage is evident in their similar amino acid sequences, three-dimensional structures, and functionalities. Such similarities often hint at a shared evolutionary past, allowing researchers and scientists to predict the function of newly discovered proteins.
Protein Superfamilies: Diving deeper into the realm of proteins, we encounter protein superfamilies. These are larger assemblies that encompass several protein families. While the members of a single protein family exhibit close resemblances, superfamilies bring together multiple families under one umbrella due to their shared structural or functional features, albeit with more distant relationships.
Beta LifeScience's extensive portfolio showcases a diverse range of proteins from various families and superfamilies, including but not limited to:
Protein Families & Superfamilies
Tumor Necrosis Factor (TNF) Superfamily
TNF and its receptors regulate immunity, inflammation, and diseases. Understanding their signaling and roles is key to comprehending related ailments and developing effective treatments.
Chemokines Family
Chemokines represent a crucial category of molecular signaling compounds with significant involvement in immune and inflammatory reactions, as well as tissue healing. Exploring chemokines and their receptors contributes to unraveling the workings of inflammatory disorders and offers novel avenues and tactics for addressing associated conditions.
Interferons (IFNs) Family
Members of the interferon family find extensive clinical application in treating diverse conditions like viral infections, tumors, and immune-related disorders. Interferon holds a pivotal function in immune response and the fight against viruses. It triggers cells' antiviral defenses, boosts immune cell performance, controls inflammation, and hampers virus growth and cell multiplication.
Colony-Stimulating Factors (CSFs) Family
Colony-stimulating factors constitute a significant group of cytokines crucial for the proper operation of the hematopoietic system and immune control. Investigating these factors and their clinical implementation aids in comprehending how hematopoiesis is regulated, and offers novel approaches and techniques for addressing associated medical conditions.
Wingless-INT (WNT) Family
The WNT Family, also known as Wingless-INT, constitutes a significant group of cellular signaling proteins encompassing various members such as WNT1, WNT2, WNT3, and more. This family holds a crucial regulatory function in processes like cellular development, tissue restoration, and the emergence of diseases.
BCL2 Gene Family
The BCL2 gene family is an important gene family, which contains multiple genes related to the regulation of apoptosis. Members of the BCL2 gene family play a key regulatory role in the process of apoptosis and are crucial to maintaining the balance between cell survival and death.
G-protein coupled receptors (GPCR)
GPCRs are a class of transmembrane proteins widely present in organisms, and they participate in the regulation of various physiological processes and signal transduction pathways. GPCRs bind to extracellular signaling molecules to trigger a series of intracellular signaling events, thereby regulating cell function and behavior.
Immunoglobulins Superfamily
Immunoglobulin superfamily (IgSF) is a family of proteins widely present in various organisms, and its members have similar structural domains and functions. Proteins of this family typically consist of a series of repeating immunoglobulin domains joined by two beta sheets (beta sheets). The immunoglobulin superfamily plays a variety of important biological functions in the body.
Kinesins Gene Family
The kinesin gene family refers to the family of protein genes that play key functions in cells, especially those closely related to the occurrence and development of diseases such as cancer. The kinesin gene family plays a key role in many cell biological processes such as cell cycle, signal transduction, DNA repair, apoptosis, angiogenesis, etc.
Matrix Metalloproteinases (MMPs)
Matrix metalloproteinases (MMPs) are a class of enzyme proteins that play an important role in the degradation and remodeling of the extracellular matrix. They specifically degrade and regulate protein components in the extracellular matrix, including collagen, elastin, and other matrix proteins.
Angiopoietin Family
Angiopoietin is a class of proteins closely related to angiogenesis and vascular stability. The angiopoietin family includes Angiopoietin-1 (Ang-1), Angiopoietin-2 (Ang-2), Angiopoietin-3 (Ang-3) and Angiopoietin-4 (Ang-4). These proteins play an important role in blood vessel development, repair and remodeling.
Neurotrophin Family
Neurotrophic factors are essential biomolecules that play pivotal roles in the development and maintenance of the nervous system. These factors, comprised of specific proteins or small signaling molecules produced internally, promote the growth, survival, and function of nerve cells. They exert important regulatory functions in the normal development, regeneration, and repair of the nervous system.
Our commitment at Beta LifeScience is not just to provide premium quality recombinant proteins but also to advance the understanding of these proteins, their families, and superfamilies. With our products and services, researchers worldwide are better equipped to delve into the mysteries of life, one protein at a time.
