Synthetic Human Macrophage inflammatory Protein 5 (Animal Free)
Beta LifeScience
SKU/CAT #: BLA-2432P
Synthetic Human Macrophage inflammatory Protein 5 (Animal Free)
Beta LifeScience
SKU/CAT #: BLA-2432P
Our products are highly customizable to meet your specific needs. You can choose options such as endotoxin removal, liquid or lyophilized forms, preferred tags, and the desired functional sequence range for proteins. Submitting a written inquiry expedites the quoting process.
Product Overview
Host Species | Human |
Accession | Q16663 |
Synonym | C-C motif chemokine 15 C-C motif chemokine ligand 15 CC chemokine 3 CCL15 CCL15(29-92) CCL15_HUMAN Chemokine (C C motif) ligand 15 Chemokine CC-2 Chemokine CC2 HCC-2 HCC2 HMRP 2B HMRP2B Leukotactin 1 Leukotactin-1 LKN-1 LKN1 Macrophage inflammatory protein 5 MIP 1D MIP-1 delta MIP-1D MIP-5 MIP1 delta MIP1d MIP5 MRP 2B Mrp-2b Mrp2b NCC 3 NCC-3 NCC3 New CC chemokine 3 OTTHUMP00000163955 SCYA15 SCYL3 Small inducible cytokine A15 Small inducible cytokine subfamily A (Cys Cys), member 15 Small-inducible cytokine A15 SY15 |
Description | Synthetic Human Macrophage inflammatory Protein 5 (Animal Free) was expressed in Synthetic. It is a Full length protein |
Source | Synthetic |
AA Sequence | Pyr-FINDAETEL MMSKLPLENP VVLNSFHFAADCCTSYISQS IPCSLMKSYF ETSSECSKPGVIFLTKKGRQ VCAKPSGPGV QDCMKKLKPYSI |
Molecular Weight | 10 kDa |
Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method |
Formulation | Lyophilised |
Stability | The recombinant protein samples are stable for up to 12 months at -80°C |
Reconstitution | See related COA |
Unit Definition | For Research Use Only |
Storage Buffer | Shipped at 4°C. Store at -20°C or -80°C. Avoid freeze / thaw cycle. |
Target Details
Target Function | Chemotactic factor that attracts T-cells and monocytes, but not neutrophils, eosinophils, or B-cells. Acts mainly via CC chemokine receptor CCR1. Also binds to CCR3. CCL15(22-92), CCL15(25-92) and CCL15(29-92) are more potent chemoattractants than the small-inducible cytokine A15. |
Subcellular Location | Secreted. |
Protein Families | Intercrine beta (chemokine CC) family |
Database References | |
Tissue Specificity | Most abundant in heart, skeletal muscle and adrenal gland. Lower levels in placenta, liver, pancreas and bone marrow. CCL15(22-92), CCL15(25-92) and CCL15(29-92) are found in high levels in synovial fluids from rheumatoid patients. |
Gene Functions References
- CCL15 secreted from SMAD4-deficient xenografted human colorectal cancer cells recruited CCR1(+) cells, promoting their metastatic activities to the lung. Lung metastases from colorectal cancer patients revealed that CCL15 expression correlated with loss of SMAD4. CCL15-positive metastases recruited approximately 1.9 times more numbers of CCR1(+) cells than CCL15-negative metastases. PMID: 27492974
- CCL15 activation of CCR1 plays critical roles in hepatocellular carcinoma metastasis. PMID: 26501423
- Orthotopic animal models of HCC were established to investigate the role of CCL15 in hMSCs migration toward HCC in vivo. Both histological and flow cytometric analysis showed that significantly fewer hMSCs localized within 97H-CCL15-shRNA xenografts compared with 97H-green fluorescent protein xenografts after intravenous delivery PMID: 26763650
- Loss of SMAD4 was significantly associated with CCL15 expression. PMID: 26341919
- follicular thyroid carcinoma (FTC) might induce tumor associated macrophages (TAMs) infiltration by producing CCL15. Measurement of TAMs and CCL15 in follicular thyroid lesions may be applied clinically to differentiate FTC from follicular adenoma PMID: 26875556
- two inflammatory cytokines, MIP-1delta and MIP-3alpha, are able to increase mesenchymal stromal cells migration in vitro PMID: 25579056
- we investigated a role of CCL15 in upregulating ICAM-1 in endothelial cells PMID: 23690481
- CCL15 is elevated in human asthma and correlates with disease severity . PMID: 22092970
- Data show that Only three of these proteins EGF, PDGF-BB and MIP-1delta (CCL15) differed significantly in plasma between controls and Alzheimer's disease (AD). PMID: 22279551
- increased secretion by macrophages during Mycobacterium tuberculosis infection PMID: 20016943
- truncation of NH2-terminal amino acid residues increases agonistic potency on CC chemokine receptors 1 and 3 PMID: 11832479
- Lkn-1 activates the ERK pathway by transducing the signal through G(i)/G(o) protein, PLC, PKC delta and Ras, and it may play a role for cell proliferation, differentiation, and regulation of gene expression for other cellular processes PMID: 12759139
- These observations demonstrate that the two NF-kappaB binding sites are essential for phorbol myristate acetate-induced leukotactin-1 (Lkn-1)/CCL15 expression in human monocytes. PMID: 15179048
- CCL15(25-92) has in vitro and in vivo angiogenic activity PMID: 15251437
- alanine-aspartic acid residues preceding the first cysteine at the NH(2)-terminus are essential for the binding and biological activity of leukotactin-1 PMID: 15894113
- Compared with full-length CCL15, proteolytically processed CCL15 isoforms with N-terminal deletions display increased potency to induce calcium fluxes and chemotactic activity on monocytes and to induce adhesiveness of mononuclear cells to fibronectin. PMID: 16034099
- Transcription of the CCL15 gene is regulated by AP-1 and NF-kappaB through MEK and JNK MAPK pathways in monocytoid cells. PMID: 16364464
- Results point to an involvement of the CCL15-CCR1 axis in the pathophysiology of chronic renal failure. PMID: 16737685
- factor NF-kappaB plays an important role in regulation of LZIP expression, and LZIP expression regulates the monocyte cell migration induced by Lkn-1 PMID: 17296613