Beta Lifesciences has accumulated an extensive experience in the development of recombinant proteins. We have rich experience in the expression of recombinant proteins (antibodies, enzymes, membrane proteins, cytokines, etc.) in any species. We provide recombinant protein expression and purification services from small-scale to large-scale. According to the customer's needs, our scientists will work with you to custom develop the recombinant proteins to your desired specifications within a realistic and suitable timeframe.
Currently, We offer four widely used cell based expression systems: bacterial (E.coli), yeast, insect and mammalian cells for protein expression.
▶ Guarantee: No proteins, No payment.
▶ One-stop service from gene synthesis to protein expression and purification.
▶ Vast experience of protein expression
▶ Proprietary Protein Expression Platform
▶ Multiple protein expression systems: E.coli, yeast, baculovirus-insect and mammalian expression systems.
▶ High-throughput and large-scale protein expression and production
▶ Competitive Price and Fast turnaround.
Recombinant Protein Expression Systems:
✔ Bacterial System
✔ Insect cells
✔ Mammalian cells
✔ Cell free
Bacterial Expression System
E.coli is the preferential one of bacterial systems for recombinant protein production and large scale fermentation as its advantages including fast rate of reproduction, ease of culture, and rich knowledge about its genetics. Bacterial protein expression service offered by Beta Lifescience provides a relatively simple, fast, and inexpensive platform for native and heterologous recombinant protein production.
Yeast Expression System
Yeast protein expression system is a ideally suitable expression system for both secretion and intracellular expression as the yeast offer relatively easy genetic manipulation and rapid growth to high cell densities on inexpensive media. Yeasts are outstanding hosts for the production of functional recombinant proteins with industrial or medical applications. Great attention has been emerged on yeast due to the inherent advantages and new developments in this host cell.The common yeast expression hosts used for recombinant proteins' expression include Saccharomyces cerevisiae, Pichia pastoris, Hansenula polymorpha, Yarrowia lipolytica, Arxula adeninivorans, Kluyveromyces lactis, and Schizosaccharomyces pombe.
Insect Expression System
Baculovirus-insect cell expression systems have the capacity to produce many recombinant proteins at high levels and they also provide significant eukaryotic protein processing capabilities. The baculovirus expression vector system (BEVS) is one of the four major expression systems of genetic engineering. BEVS has several advantages of using the baculovirus-insect cell expression system, such as improved solubility and comprehensive post-translational modifications.
Mammalian Expression System
Expression systems utilizing mammalian cells for recombinant proteins are able to introduce proper protein folding, post-translational modifications, and product assembly, which are important for complete biological activity. Mammalian cells are currently the main hosts for commercial production of therapeutic proteins, including monoclonal antibody (mAbs).There are two ways for protein expression of mammalian cells: transient transfection and stable transfection. HEK293 or CHO cells are often used in transient transfection. A small amount of protein can be quickly obtained within one week after the transient transfection.
How to Select the Protein Expression Systems:
Flow chart of protein production:
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