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Recombinant Mouse Cathepsin D Protein (His Tag)

Cat No.: BLPSN-0601
CatD Protein, Mouse; CD Protein, Mouse
Description Related products
tag His
host species Mouse
accession NP_034113.1
synonym CatD, CD
background Cathepsin D (CTSD), a well known lysosomal aspartyl protease and belongs to the peptidase C1 family, which is a normal and major component of lysosomes, and is found in almost all cells and tissues of mammals. Its mostly described function is intracellular catabolism in lysosomal compartments, other physiological effect include hormone and antigen processing. Cathepsin D has a specificity similar to but narrower than that of pepsin A. Cathepsin D plays an important role in the degradation of proteins, the generation of bioactive proteins, antigen processing, etc. Among different role in cell physiology, a new function of this enzyme is examined. Cathepsin D is an important regulator of apoptotic pathways in cells. It acts at different stage of intrinsic and extrinsic pathway of apoptosis. In addition, CTSD secreted from human prostate carcinoma cells are responsible for the generation of angiostatin, a potent endogenous inhibitor of angiogenesis, suggesting its contribution to the prevention of tumor growth and angiogenesis-dependent growth of metastases.
description A DNA sequence encoding the mouse CTSD (NP_034113.1) precursor (Met 1-Leu 410) was expressed with a His tag at the C-terminus.
source HEK293
predicted n terminal Ile 21
AA sequence Met 1-Leu 410
molecular weight The secreted recombinant mouse CTSD pro form consists of 401 a.a. and has a predicted molecular mass of 44.4 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rmCTSD is approximately 48 kDa due to glycosylation.
purity >96% as determined by SDS-PAGE
endotoxin < 1.0 EU per μg of the protein as determined by the LAL method
bioactivity Please contact us for detailed information
formulation Lyophilized from sterile PBS, pH 7.4.
stability The recombinant proteins are stable for up to 1 year from date of receipt at -70℃.
usage For Research Use Only
storage Store the protein under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Cat No. Product Name Source Detail Inquiry
BLPSN-0600 Recombinant Human Cathepsin D Protein (His Tag) HEK293
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