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Recombinant Mouse Cathepsin A Protein (His Tag)

Cat No.: BLPSN-0595
AU019505 Protein, Mouse; PPCA Protein, Mouse; Ppgb Protein, Mouse
Description Related products
tag His
host species Mouse
accession P16675
synonym AU019505, PPCA, Ppgb
background Lysosomal carboxypeptidase, cathepsin A (protective protein, CathA), is a component of the lysosomal multienzyme complex along with beta-galactosidase (GAL) and sialidase Neu1, where it activates Neu1 and protects GAL and Neu1 against the rapid proteolytic degradation. Cathepsin A is a multicatalytic enzyme with deamidase and esterase in addition to carboxypeptidase activities. It was recently identified in human platelets as deamidase. In vitro, it hydrolyzes a variety of bioactive peptide hormones including tachykinins, suggesting that extralysosomal cathepsin A plays a role in regulation of bioactive peptide functions. It is a member of the alpha/beta hydrolase fold family and has been suggested to share a common ancestral relationship with other alpha/beta hydrolase fold enzymes, such as cholinesterases. Cathepsin A defects are linked to multiple forms of Galactosialidosis with a combined secondary deficiency of beta-galactosidase and neuraminidase. Cathepsin A is a key molecule in the onset of galactosialidosis and also highlight the therapeutic acts in vivo as an endothelin-1-inactivating enzyme and strongly confirm a crucial role of this enzyme in effective elastic fiber formation.
description A DNA sequence encoding the mouse CTSA (P16675-1) (Met 1-Tyr 474) was expressed, with a C-terminal His tag.
source HEK293
predicted n terminal Ala 24
AA sequence Met 1-Tyr 474
molecular weight The secreted recombinant mouse CTSA consists of 462 a.a. and has a calculated molecular mass of 52.8 kDa as estimated in SDS-PAGE under reducing conditions.
purity >96% as determined by SDS-PAGE
endotoxin < 1.0 EU per μg of the protein as determined by the LAL method
bioactivity Please contact us for detailed information
formulation Lyophilized from sterile 25mM Tris, 0.3M NaCl, pH 8.0.
stability The recombinant proteins are stable for up to 1 year from date of receipt at -70℃.
usage For Research Use Only
storage Store the protein under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Cat No. Product Name Source Detail Inquiry
BLPSN-0594 Recombinant Human Cathepsin A Protein (His Tag) HEK293
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