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Recombinant Mouse BACE2 Protein (His Tag)

Cat No.: BLPSN-0342
1110059C24Rik Protein, Mouse; AEPLC Protein, Mouse; AI850424 Protein, Mouse; ALP56 Protein, Mouse; ARP1 Protein, Mouse; ASP21 Protein, Mouse; BAE2 Protein, Mouse; CDA13 Protein, Mouse; CEAP1 Protein, Mouse; DRAP Protein, Mouse
Description
tag His
host species Mouse
accession Q9JL18
synonym 1110059C24Rik, AEPLC, AI850424, ALP56, ARP1, ASP21, BAE2, CDA13, CEAP1, DRAP
background BACE2, also known as beta secretase 2, belongs to the peptidase A1 family. It is a protease known to be an important enzyme involved in the cellular pathways. BACE2 has been shown to interact with GGA1 and GGA2. It is the major β-secretase in vivo. BACE2 is located on chromosome 21 and may play a role in alzheimer's disease pathogenesis in down syndrome(DS). Overexpression of BACE2 by lentivirus markedly reduced amyloid β protein production in primary neurons. Despite an extra copy of the BACE2 gene in DS and the increase of its transcription, BACE2 protein levels are unchanged.
description A DNA sequence encoding the mouse BACE2 (Q9JL18) (Met1-Pro462) was expressed with a C-terminal His tag.
source HEK293
predicted n terminal Ala 20
AA sequence Met1-Pro462
molecular weight The recombinant mouse BACE2 comprises 454 a.a. and has a predicted molecular mass of 49.2 kDa. The apparent molecular mass of the protein is approximately 55 kDa in SDS-PAGE under reducing conditions due to glycosylation.
purity >95% as determined by SDS-PAGE
endotoxin < 1.0 EU per μg of the protein as determined by the LAL method
bioactivity Measured by its ability to cleave a fluorogenic peptide substrate Mca-KPLGL-Dpa-AR-NH2 .The specific activity is >50 pmoles/min/ug.
formulation Lyophilized from sterile PBS, pH 7.4.
stability The recombinant proteins are stable for up to 1 year from date of receipt at -70℃.
usage For Research Use Only
storage Store the protein under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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