Recombinant Human OX40 Protein (His Tag), Biotinylated
Beta LifeScience
SKU/CAT #: BLPSN-3616
Recombinant Human OX40 Protein (His Tag), Biotinylated
Beta LifeScience
SKU/CAT #: BLPSN-3616
Our products are highly customizable to meet your specific needs. You can choose options such as endotoxin removal, liquid or lyophilized forms, preferred tags, and the desired functional sequence range for proteins. Submitting a written inquiry expedites the quoting process.
Product Overview
Tag | His |
Host Species | Human |
Accession | NP_003318.1 |
Synonym | OX40 Tumor necrosis factor receptor superfamily member 4; ACT35 antigen; OX40L receptor; TAX transcriptionally-activated glycoprotein 1 receptor; CD134; TNFRSF4; TXGP1L |
Background | OX40, also termed CD134 and TNFRSF4, is a T cell co-stimulatory molecule of the TNF receptor superfamily which plays a key role in the survival and homeostasis of effector and memory T cells. OX40 is expressed on CD4+ and CD8+ T cells upon engagement of the TCR by antigen presenting cells along with co-stimulation by CD40-CD40 Ligand and CD28-B7. The interaction between OX40 and OX40 ligand (OX40L) will occur when activated T cells bind to professional antigen-presenting cells (APCs). The T-cell functions, including cytokine production, expansion, and survival, are then enhanced by the OX40 costimulatory signals. OX40 signals are critical for controlling the function and differentiation of Foxp3+ regulatory T cells. OX40-OX40L interaction regulates T-cell tolerance, peripheral T-cell homeostasis, and T-cell-mediated inflammatory diseases. |
Description | A DNA sequence encoding the extracellular domain (Met1-Ala216) of human TNFRSF4 (NP_003318.1) was produced, fused with a His tag at the C-terminus. The purified protein was biotinylated in vitro. |
Source | HEK293 |
Predicted N Terminal | Leu 29 |
AA Sequence | Met1-Ala216 |
Molecular Weight | The recombinant human TNFRSF4 consists of 199 amino acids and has a predicted molecular mass of 21.7 kDa. |
Purity | Greater than 80% as determined by SDS-PAGE |
Endotoxin | < 1.0 EU per μg protein as determined by the LAL method. |
Bioactivity | Measured by its ability to bind human TNFSF4-Fc in functional ELISA. |
Formulation | Lyophilized from sterile PBS,pH7.4. |
Stability | Recombinnat Proteins are stable for up to 1 year from date of receipt at -70°C |
Usage | For Research Use Only |
Storage | Store recombinant protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |