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Recombinant Human MICA Protein (Fc Tag)

Cat No.: BL-0015NP
Description Related products
tag Fc
host species Human
accession Q29983
synonym MICA MHC Class I Polypeptide-Related Sequence A; MIC-A; MICA; PERB11.1
background MHC class I polypeptide-related sequence A, also known as MIC-A, PERB11.1 and MICA, is a single-pass type I membrane protein which belongs to the MHC class I family of MIC subfamily. MICA contains one Ig-like C1-type domain and is expressed on the cell surface, although unlike canonical class I molecules does not seem to associate with beta-2-microglobulin. It is thought that MICA functions as a stress-induced antigen that is broadly recognized by NK cells, NKT cells, and most of the subtypes of T cells. MICA is the ligand for NK cell activating receptor KLRK1/NKG2D. MICA seems to have no role in antigen presentation. MICA leads to cell lysis by binding to KLRK1.
description Recombinant Human MHC Class I Polypeptide-Related Sequence A is expressed by our Mammalian expression system and the target gene encoding Ala23-Glu308 is expressed with a Fc tag at the C-terminus.
source Human Cells
AA sequence Ala23-Glu308
purity >95% as determined by reducing SDS-PAGE.
endotoxin <0.1 ng/µg (1 EU/µg) as determined by LAL test.
bioactivity Measured by its ability to bind Human N2DL2 in functional ELISA. The ED50 for this effect is less than 5 ug/ml.
formulation Recombinant Human MICA Protein was lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
reconstitution Dissolve the lyophilized protein in distilled water.
usage For Research Use Only
storage Human MICA protein should be stored at < -20°C, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7°C for 2-7 days.Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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