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| tag | Fc |
| host species | Human |
| accession | Q29983 |
| synonym | MICA MHC Class I Polypeptide-Related Sequence A; MIC-A; MICA; PERB11.1 |
| background | MHC class I polypeptide-related sequence A, also known as MIC-A, PERB11.1 and MICA, is a single-pass type I membrane protein which belongs to the MHC class I family of MIC subfamily. MICA contains one Ig-like C1-type domain and is expressed on the cell surface, although unlike canonical class I molecules does not seem to associate with beta-2-microglobulin. It is thought that MICA functions as a stress-induced antigen that is broadly recognized by NK cells, NKT cells, and most of the subtypes of T cells. MICA is the ligand for NK cell activating receptor KLRK1/NKG2D. MICA seems to have no role in antigen presentation. MICA leads to cell lysis by binding to KLRK1. |
| description | Recombinant Human MHC Class I Polypeptide-Related Sequence A is expressed by our Mammalian expression system and the target gene encoding Ala23-Glu308 is expressed with a Fc tag at the C-terminus. |
| source | Human Cells |
| AA sequence | Ala23-Glu308 |
| purity | >95% as determined by reducing SDS-PAGE. |
| endotoxin | <0.1 ng/µg (1 EU/µg) as determined by LAL test. |
| bioactivity | Measured by its ability to bind Human N2DL2 in functional ELISA. The ED50 for this effect is less than 5 ug/ml. |
| formulation | Recombinant Human MICA Protein was lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. |
| reconstitution | Dissolve the lyophilized protein in distilled water. |
| usage | For Research Use Only |
| storage | Human MICA protein should be stored at < -20°C, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7°C for 2-7 days.Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
| Cat No. | Product Name | Source | Detail | Inquiry |
| BLPSN-3362 | Recombinant Human MICA Protein (His Tag) | HEK293 |  |
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| BLA-5798P | Recombinant Human MICA Protein | E.coli | |
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| BLA-5799P | Recombinant Human MICA Protein | HEK293 | |
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| BLA-5800P | Recombinant Human MICA Protein | E.coli | |
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| BLA-5801P | Recombinant Human MICA Protein | HEK293 | |
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| BL-3513PS | Recombinant Human MICA Protein | E.coli | |
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| BL-3514PS | Recombinant Human MICA Protein (His Tag) | E.coli | |
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| BL-1227NP | Recombinant Human MICA Protein (His Tag) | Human Cells | |
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