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Recombinant Human KIF5B-ALK (Kex24Aex20) Protein

Cat No.: BL-0007SG
Description Related products
tag GST
host species Human
accession NM_004521NM_004304
synonym KIF5B: KINH, UKHC, KNSALK: ALK (Ki-1), CD246
background Anaplastic large cell lymphomas are associated with chromosomal aberrations involving the anaplastic lymphoma kinase (ALK) gene, resulting in the expression of novel chimeric ALK proteins with transforming properties. Many chromosomal rearrangements leading to enhanced ALK activity have been described and are implicated in a number of cancer types (1). A fusion protein of kinesin family member 5B (KIF5B) exon 15 to ALK exon 20 has been reported in a primary lung adenocarcinoma (2). Overexpression of KIF5B-ALK increased cell proliferation, migration and invation via activating the STAT3 and PKB (3).
description Recombinant human fusion KIF5B (1-921a.a., exons1-24) - ALK (1058a.a.-end, exons20-29) protein was produced by baculovirus in Sf9 insect cells, fused with a GST tag at N-terminus. This protein is purified with our unique purification methods.
source Sf9 insect cells
AA sequence 1058a.a.-end, exons20-29
molecular weight 195 kDa
purity For specific purity information on a given lot, see related COA.
endotoxin < 1.0 EU per μg of the protein as determined by the LAL method
bioactivity Active
formulation Recombinant protein is supplied in 50mM Tris-HCl, pH 7.5, 50mM NaCl, 10mM Glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF and 25% glycerol.
stability The recombinant protein is stable for up to 12 months at -70℃
usage For Research Use Only
storage Recombinant Human KIF5B-ALK (Kex24Aex20) Protein should be stored should be stored at < -70°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Cat No. Product Name Source Detail Inquiry
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BL-0095SG Recombinant Human KIF5B-RET (V804M) Protein Sf9 insect cells
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BL-0108SG Recombinant Human KIF5B-MET (Kex24Mex14) Protein Sf9 insect cells
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