Recombinant Human Interferon Gamma / IFNG Protein
Beta LifeScience
SKU/CAT #: BLPSN-2995
Recombinant Human Interferon Gamma / IFNG Protein
Beta LifeScience
SKU/CAT #: BLPSN-2995
Our products are highly customizable to meet your specific needs. You can choose options such as endotoxin removal, liquid or lyophilized forms, preferred tags, and the desired functional sequence range for proteins. Submitting a written inquiry expedites the quoting process.
Product Overview
Tag | N/A |
Host Species | Human |
Accession | NP_000610.2 |
Synonym | IFG, IFI, IFN gamma, Interferon Gamma |
Background | IFN gamma, also known as IFNG, is a secreted protein which belongs to the type I I interferon family. IFN gamma is produced predominantly by natural killer and natural killer T cells as part of the innate immune response, and by CD4 and CD8 cytotoxic T lymphocyte effector T cells once antigen-specific immunity develops. IFN gamma has antiviral, immunoregulatory, and anti-tumor properties. IFNG, in addition to having antiviral activity, has important immunoregulatory functions, it is a potent activator of macrophages, and has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. The IFNG monomer consists of a core of six alpha-helices and an extended unfolded sequence in the C-terminal region. IFN gamma is critical for innate and adaptive immunity against viral and intracellular bacterial infections and for tumor control. Aberrant IFN gamma expression is associated with a number of autoinflammatory and autoimmune diseases. The importance of IFN gamma in the immune system stems in part from its ability to inhibit viral replication directly, and most importantly from its immunostimulatory and immunomodulatory effects. IFNG also promotes NK cell activity.Immune CheckpointImmunotherapyCancer ImmunotherapyTargeted Therapy |
Description | A DNA sequence encoding the human IFNG (NP_000610.2) (Met 1-Gln 166) was expressed and purified. |
Source | CHO Stable Cells |
Predicted N Terminal | Gln 24 |
AA Sequence | Met 1-Gln 166 |
Molecular Weight | The secreted recombinant human IFNG consists of 143 a.a. and has a predicted molecular mass of 16.7 kDa. |
Purity | >(59.9+28.9)% as determined by SDS-PAGE |
Endotoxin | < 1.0 EU per mg of the protein as determined by the LAL method |
Bioactivity | Measured in antiviral assays using WISH human amnion cells infected with vesicular stomatitis virus(VSV). The EC50 for this effect is typically 0.07-0.4ng/mL. |
Formulation | Lyophilized from sterile PBS, pH 7.4. |
Stability | The recombinant proteins are stable for up to 1 year from date of receipt at -70°C. |
Usage | For Research Use Only |
Storage | Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |