Recombinant Human IL17RA Protein (His Tag), Biotinylated
Beta LifeScience
SKU/CAT #: BLPSN-2726
Recombinant Human IL17RA Protein (His Tag), Biotinylated
Beta LifeScience
SKU/CAT #: BLPSN-2726
Our products are highly customizable to meet your specific needs. You can choose options such as endotoxin removal, liquid or lyophilized forms, preferred tags, and the desired functional sequence range for proteins. Submitting a written inquiry expedites the quoting process.
Product Overview
Tag | His |
Host Species | Human |
Accession | NP_055154.3 |
Synonym | CANDF5, CD217, CDw217, hIL-17R, IL-17RA, IL17R |
Background | Interleukin-17 receptor (IL-17R), also known as Interleukin-17 receptor A (IL-17RA) and CD217 antigen (CD217), is a cytokine receptor which binds interleukin 17. IL-17R/IL-17RA (CD217) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. IL-17R/IL-17RA (CD217) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor IL-17RA play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. Defects in IL-17R/IL-17RA (CD217) are the cause of familial candidiasis type 5 (CANDF5). CANDF5 is a rare disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans. |
Description | A DNA sequence encoding the IL17RA (NP_055154.3) (Met1-Trp320) was expressed with a C-terminal His tag. The purified protein was biotinylated in vitro. |
Source | HEK293 |
Predicted N Terminal | Leu 33 |
AA Sequence | Met1-Trp320 |
Molecular Weight | The recombinant IL17RA consists of 299 a.a. and predicts a molecular mass of 34.9 kDa. |
Purity | >95% as determined by SDS-PAGE. |
Endotoxin | < 1.0 EU per μg protein as determined by the LAL method. |
Bioactivity | Please contact us for detailed information |
Formulation | Lyophilized from sterile Sterile PBS.. |
Stability | The recombinant proteins are stable for up to 1 year from date of receipt at -70°C. |
Usage | For Research Use Only |
Storage | Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |