Tel: 1-201-888-7983
E-mail: info@betalifesci.com
| tag | Fc |
| host species | Human |
| accession | NP_001973.2 |
| synonym | ERBB3, ErbB-3, HER3, LCCS2, MDA-BF-1, c-erbB-3, c-erbB3, erbB3-S, p180-ErbB3, p45-sErbB3, p85-sErbB3, erb-b2 receptor tyrosine kinase 3, FERLK |
| background | Receptor tyrosine-protein kinase erbB-3, also known as HER3 (human epidermal growth factor receptor 3), is a membrane bound protein that in humans is encoded by the ERBB3 gene.ErbB3 is a member of the epidermal growth factor receptor (EGFR/ERBB) family of receptor tyrosine kinases. The kinase-impaired ErbB3 is known to form active heterodimers with other members of the ErbB family, most notably the ligand binding-impaired ErbB2.ERBB3 (Erb-B2 Receptor Tyrosine Kinase 3) is a Protein Coding gene. Diseases associated with ERBB3 include Lethal Congenital Contracture Syndrome 2 and Erythroleukemia, Familial. Among its related pathways are PI3K/AKT activation and RET signaling. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and transferase activity, transferring phosphorus-containing groups. An important paralog of this gene is ERBB4. |
| description | A DNA sequence encoding the extracellular domain (Met 1-Thr 643) of human ErbB3 (NP_001973.2) precursor was expressed with the C-terminal fused Fc region of human IgG1. |
| source | HEK293 |
| predicted n terminal | Ser 20 |
| AA sequence | Met 1-Thr 643 |
| molecular weight | The mature recombinant human ErbB3/Fc chimera is a disulfide-linked homodimeric protein after the removal of signal peptide. The monomer consists of 862 amino acids and has a calculated molecular mass of 95.4 kDa. As a result of glycosylation, the recombinant monomer migrates as an approximately 130-140 kDa protein in SDS-PAGE under reducing conditions. |
| purity | >90% as determined by SDS-PAGE |
| endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method |
| bioactivity | Measure by its ability to bind with human NRG1-β1 in a functional ELISA. |
| formulation | Recombinant Human HER3 / ERBB3 Protein (Fc Tag) was lyophilized from sterile PBS, pH 7.4 |
| stability | Recombinant Human HER3 / ERBB3 protein is stable up to 1 year at -70℃ |
| usage | For Research Use Only |
| storage | Store the protein under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
