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Recombinant Human F8 Protein

Cat No.: BL-2924PL
Coagulation Factor-VIII Human Recombinant
Description Related products
tag N/A
host species Human
accession P00451
synonym F8, AHF, DXS1253E, F8B, F8C, FVIII, HEMA, coagulation factor VIII
background Factor VIII (FVIII) is an essential blood-clotting protein, also known as anti-hemophilic factor (AHF). In humans, factor VIII is encoded by the F8 gene. Defects in this gene result in hemophilia A, a recessive X-linked coagulation disorder. Factor VIII is produced in liver sinusoidal cells and endothelial cells outside the liver throughout the body. This protein circulates in the bloodstream in an inactive form, bound to another molecule called von Willebrand factor, until an injury that damages blood vessels occurs. In response to injury, coagulation factor VIII is activated and separates from von Willebrand factor. The active protein (sometimes written as coagulation factor VIIIa) interacts with another coagulation factor called factor IX. This interaction sets off a chain of additional chemical reactions that form a blood clot.
description Recombinant Human Antihemophilic Facor 8 produced in CHO is a glycosylated polypeptide chain having 2,322aa. The Factor-VIII protein is purified using our unique purification techniques.
source CHO
purity >97.0% as determined by SDS-PAGE.
endotoxin <1.0 EU per μg of F8 protein by the LAL method.
bioactivity The specific activity of Factor 8 protein was found to be 7,058 IU/mg.
formulation Recombinant F8 protein was lyophilized from a solution containing 8mg Tween-80, 112mM NaCl, 40mg Mannitol, 10mg Trehalose, 1ng VWF and 4.2mM CaCl2.
usage For Research Use Only
storage Lyophilized Factor-VIII although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Factor-VIII should be stored at 4°C between 2-7 days and for future use below -18°C. Please prevent freeze-thaw cycles.
Cat No. Product Name Source Detail Inquiry
BL-2924PS Recombinant Human F8 Protein Human Plasma
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