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Recombinant Human EML4-ALK (Eex6Aex20) Protein

Cat No.: BL-0011SG
Description Related products
tag GST
host species Human
accession NM_019063NM_004304
synonym EML4: C2orf2, EMAPL4ALK: ALK (Ki-1), CD246
background ALK or CD246 is a receptor tyrosine kinase, which belongs to the insulin receptor superfamily which comprises an extracellular domain, a hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. CD246 plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. ALK-positive neoplasms represent a distinct entity because the morphology of the tumors is often neither anaplastic nor large cell and the tumors should be referred to as ALK lymphomas (1). CD246 has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. EML4-ALK mutations in lung cancer confer resistance to ALK inhibitors (2).
description Recombinant human fusion protein EML4 (1-222) - ALK (1058-end) was produced by baculovirus in Sf9 insect cells, fused with a GST tag at N-terminus. This protein is purified with our unique purification methods.
source Sf9 insect cells
AA sequence 1058a.a.-end
molecular weight 118 kDa
purity For specific purity information on a given lot, see related COA.
endotoxin < 1.0 EU per μg of the protein as determined by the LAL method
bioactivity Active
formulation Recombinant protein is supplied in 50mM Tris-HCl, pH 7.5, 50mM NaCl, 10mM Glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF and 25% glycerol.
stability The recombinant protein is stable for up to 12 months at -70℃
usage For Research Use Only
storage Recombinant Human EML4-ALK (Eex6Aex20) Protein should be stored should be stored at < -70°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Cat No. Product Name Source Detail Inquiry
BL-0012SG Recombinant Human EML4-ALK (Eex14Aex20) Protein Sf9 insect cells
BL-0013SG Recombinant Human EML4-ALK (Eex20Aex20) Protein Sf9 insect cells
BL-0250SG Recombinant Human EML4 & ALK Fusion Protein Sf9 insect cells
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