Recombinant Human CXCL17 Protein (His Tag)
Beta LifeScience
SKU/CAT #: BL-0147PS
Recombinant Human CXCL17 Protein (His Tag)
Beta LifeScience
SKU/CAT #: BL-0147PS
Our products are highly customizable to meet your specific needs. You can choose options such as endotoxin removal, liquid or lyophilized forms, preferred tags, and the desired functional sequence range for proteins. Submitting a written inquiry expedites the quoting process.
Product Overview
Tag | His |
Host Species | Human |
Synonym | Dcip1, DMC, MGC138300, UNQ473, VCC-1, VCC1, VEGFcoregulated chemokine 1, C-X-C motif chemokine 17, Dendritic cell and monocytechemokine-like protein. |
Background | Dendritic cell and monocyte chemokinelike protein (DMC/CXCL17/VEGF-correlated chemokine 1/VCC1), is a secreted molecule with a size and predicted 3-dimensional folding pattern similar to that of chemokines CXCL8/IL8 and CXCL14/BRAK. CXCL17 is constitutively generated by airway and intestinal epithelium. CXCL17 induces the chemotaxis of quiescent, but not LPS-activated peripheral blood monocytes and dendritic cells, and it also binds these cells specifically. The expression of CXCL17 is increased in endothelial cells when they are induced to form tubes in vitro. CXCL17, CXCL1/CXCL1nd CXCL8/IL8 which have roles in angiogenesis, show significantly correlated expression with that of VEGF in primary lung, breast and esophageal tumors. Therefore, CXCL17 is suggested to have a role in tumor angiogenesis. The mature Rat CXCL17 shares 82%, 71% amino acid sequence identity with mouse, human CXCL17, respectively. |
Description | CXCL17 Human Recombinant expressed in E.Coli is a single,non-glycosylated polypeptide chain containing 119a.a. (22-119 a.a) andhaving a molecular weight of 13.7kDa.CXCL17 is fused to a 21a.a. His-tag at N-terminusand purified by unique purification methods. |
Source | E.coli |
AA Sequence | MGSSHHHHHH SSGLVPRGSH MSSLNPGVAR GHRDRGQASR RWLQEGGQEC ECKDWFLRAP RRKFMTVSGL PKKQCPCDHFKGNVKKTRHQ RHHRKPNKHS RACQQFLKQC QLRSFALPL. |
Purity | >85.0% as determined by SDS-PAGE. |
Endotoxin | <1.0 EU per μg by the LAL method. |
Formulation | CXCL17 protein solution (0.5mg/ml) contains 20mM Tris-HClbuffer (pH 8.0), 0.4M Urea and 10% glycerol. |
Stability | Recombinant protein is stable for 12 months at -70°C |
Usage | For Research Use Only |
Storage | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |