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Recombinant Human CD47 Protein (Fc Tag)

Cat No.: BL-2149NP
Description Related products
tag Fc
host species Human
accession Q08722
synonym Leukocyte surface antigen CD47; Antigenic surface determinant protein OA3; Integrin-associated protein; IAP; Protein MER6; CD47; MER6
background CD47(Integrin-Associated Protein,IAP) is a 40 ‑ 60 kDa variably glycosylated atypical member of the immunoglobulin superfamily. The ubiquitously expressed CD47 binds to SIRP family members on macrophages, neutrophils, and T cells. CD47 is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. The protein is also a receptor for the C-terminal cell-binding domain of thrombospondin, and it may play a role in membrane transport and signal transduction. This protein has broad tissue distribution, and is reduced in expression on Rh erythrocytes.
description Recombinant Human Leukocyte Surface Antigen CD47 is produced by our Mammalian expression system and the target gene encoding Gln19-Pro139 is expressed with a mFc tag at the C-terminus.
source Human Cells
AA sequence Gln19-Pro139
purity >95% as determined by reducing SDS-PAGE.
endotoxin Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test.
bioactivity Immobilized Human SIRPA-His (Cat#BL-0438NP) at 0.8μg/ml (100 μl/well) can bind Human CD47-Fc (Cat#BL-2149NP). The ED50 of Human CD47-Fc (Cat#BL-2149NP) is 0.5-2.0 μg/mL .
formulation Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
stability Recombinant Human CD47 protein is stable for 1 year at -70℃
reconstitution Dissolve the lyophilized protein in distilled water.
usage For Research Use Only
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