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Recombinant Human Cathepsin D Protein (His Tag)

Cat No.: BLPSN-0600
CLN10 Protein, Human; CPSD Protein, Human; HEL-S-130P Protein, Human
Description Related products
tag His
host species Human
accession P07339
synonym CLN10, CPSD, HEL-S-130P
background Cathepsin D (CTSD), a well known lysosomal aspartyl protease and belongs to the peptidase C1 family, which is a normal and major component of lysosomes, and is found in almost all cells and tissues of mammals. Its mostly described function is intracellular catabolism in lysosomal compartments, other physiological effect include hormone and antigen processing. Cathepsin D has a specificity similar to but narrower than that of pepsin A. Cathepsin D plays an important role in the degradation of proteins, the generation of bioactive proteins, antigen processing, etc. Among different role in cell physiology, a new function of this enzyme is examined. Cathepsin D is an important regulator of apoptotic pathways in cells. It acts at different stage of intrinsic and extrinsic pathway of apoptosis. In addition, CTSD secreted from human prostate carcinoma cells are responsible for the generation of angiostatin, a potent endogenous inhibitor of angiogenesis, suggesting its contribution to the prevention of tumor growth and angiogenesis-dependent growth of metastases.
description A DNA sequence encoding the pro form of human CTSD (P07339) (Met 1-Leu 412) was fused with a His tag at the C-terminus.
source HEK293
predicted n terminal Ser 19
AA sequence Met 1-Leu 412
molecular weight The secreted recombinant human CTSD (pro form) consists of 405 a.a. and has a predicted molecular mass of 44 kDa. As a result of different glycosylation, the apparent molecular mass of rhCTSD is approximately 40-110 kDa in SDS-PAGE under reducing conditions.
purity >97% as determined by SDS-PAGE
endotoxin < 1.0 EU per μg of the protein as determined by the LAL method
bioactivity Measured by its ability to bind biotinylated human CTSS-His in a functional ELISA.
formulation Lyophilized from sterile 25mM MES, 150mM NaCl, pH 6.5.
stability The recombinant proteins are stable for up to 1 year from date of receipt at -70℃.
usage For Research Use Only
storage Store the protein under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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