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Recombinant Human ARRB1 Protein (His Tag)

Cat No.: BL-0004NP
tag His
host species Human
accession P49407
synonym ARRB1 Beta-Arrestin-1; Arrestin Beta-1; ARRB1; ARR1
background β-Arrestin-1 (ARRB1) is a cytoplasmic protein that belongs to the arrestin family. ARRB1 is expressed at high levels in peripheral blood leukocytes and the central nervous system. ARRB1 regulates agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. ARRB1 acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. ARRB1 is believed to play a major role in regulating receptor-mediated immune functions. ARRB1 is involved in Toll-like receptor and IL-1 receptor signaling through the interaction with TRAF6.
description Recombinant Human beta-Arrestin 1 is expressed by our E.coli expression system and the target gene encoding Met1-Arg418 is expressed with a His tag at the C-terminus.
source E.coli
AA sequence Met1-Arg418
purity >95% as determined by reducing SDS-PAGE.
endotoxin <0.1 ng/µg (1 EU/µg) as determined by LAL test.
formulation Recombinant Human ARRB1 Protein was lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2.
reconstitution Dissolve the lyophilized protein in distilled water.
usage For Research Use Only
storage Human ARRB1 protein should be stored at < -20°C, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7°C for 2-7 days.Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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