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Recombinant Human ACVR2A Protein (His&Fc Tag)

Cat No.: BL-1237NP
Description Related products
tag His&Fc
host species Human
accession P27037
synonym ACVR2A Activin Receptor Type-2A; Activin Receptor Type IIA; ACTR-IIA; ACTRIIA; ACVR2A; ACVR2
background Activin Receptor Type-2A is a protein that in humans is encoded by the ACVR2A gene. ACVR2A is an activin type 2 receptor. This gene encodes activin A type II receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases.
description Recombinant Human Activin Receptor Type-2A is expressed by our Mammalian expression system and the target gene encoding Ala20-Pro134 is expressed with a Fc, His tag at the C-terminus.
source Human Cells
AA sequence Ala20-Pro134
purity >95% as determined by reducing SDS-PAGE.
endotoxin <0.1 ng/µg (1 EU/µg) as determined by LAL test.
formulation Recombinant Human ACVR2A Protein was lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
reconstitution Dissolve the lyophilized protein in distilled water.
usage For Research Use Only
storage Human ACVR2A protein should be stored at < -20°C, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7°C for 2-7 days.Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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