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Recombinant Human ACE2 Protein (His Tag)

Cat No.: BL-0315NP
Description Related products
tag His
host species Human
accession Q9BYF1
synonym ACE-2 Angiotensin-Converting Enzyme 2; ACE-Related Carboxypeptidase; Angiotensin-Converting Enzyme Homolog; ACEH; Metalloprotease MPROT15; ACE2
background Angiotensin-Converting Enzyme 2 (ACE-2) is an integral membrane protein and a zinc metalloprotease of the ACE family, the ACE family includes somatic and germinal ACE. ACE-2 cleaves angiotensins I and II as a carboxypeptidase, ACE-2 converts angiotensin I to angiotensin 1-9, and angiotensin II to angiotensin 1-7. ACE-2 is also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. ACE-2 can be high expressed in testis, kidney and heart, in colon, small intestine and ovary at moderate levels. Captopril and lisinopril as the classical ACE inhibitor don’t inhibit ACE-2 activity. ACE-2 may play an important role in regulating the heart function.
description Recombinant Human Angiotensin-Converting Enzyme 2 is expressed by our Mammalian expression system and the target gene encoding Gln18-Ser740 is expressed with a His tag at the C-terminus.
source Human Cells
AA sequence Gln18-Ser740
purity >95% as determined by reducing SDS-PAGE.
endotoxin <0.1 ng/µg (1 EU/µg) as determined by LAL test.
bioactivity Immobilized Human ACE-2-His at 10μg/ml (100 μl/well) can bind 2019-nCoV S Protein RBD-mFc (Cat#BLPSN-0992P). The ED50 of Recombinant 2019-nCoV S Protein RBD-mFc (Cat#BLPSN-0992P) is 62 ng/ml .
formulation Recombinant Human ACE-2 Protein was supplied as a 0.2 μm filtered solution of 20mM TrisHCl, 150mM NaCl, 0.1mM ZnCl2, 10% Glycerol, pH 7.5.
usage For Research Use Only
storage Human ACE-2 protein should be stored at < -20°C, stable for 6 months after receipt.Please minimize freeze-thaw cycles.
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