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Recombinant Human ACE2 Protein (Fc Tag)

Cat No.: BLS-0997NP
Description Related products
tag Fc
host species Human
accession Q9BYF1
synonym ACE-2 Angiotensin-Converting Enzyme 2; ACE-Related Carboxypeptidase; Angiotensin-Converting Enzyme Homolog; ACEH; Metalloprotease MPROT15; ACE2
background Angiotensin-Converting Enzyme 2 (ACE-2) is an integral membrane protein and a zinc metalloprotease of the ACE family, the ACE family includes somatic and germinal ACE. ACE-2 cleaves angiotensins I and II as a carboxypeptidase, ACE-2 converts angiotensin I to angiotensin 1-9, and angiotensin II to angiotensin 1-7. ACE-2 is also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. ACE-2 can be high expressed in testis, kidney and heart, in colon, small intestine and ovary at moderate levels. Captopril and lisinopril as the classical ACE inhibitor don’t inhibit ACE-2 activity. ACE-2 may play an important role in regulating the heart function.
description Recombinant Human Angiotensin-Converting Enzyme 2 / ACE2 is produced in human cells and the target gene encoding Gln18-Ser740 is expressed with a Fc tag at the C-terminus.
source Human Cells
AA sequence Gln18-Ser740
molecular weight 110.5kDa. AP Mol Mass 110-140kDa, reducing conditions
purity > 95 % as determined by SDS-PAGE.
endotoxin <1.0 EU per μg human ACE2 protein as determined by the LAL method.
bioactivity Immobilized Human ACE-2-FC(Cat#BLS-0997NP) at 10μg/ml (100 μl/well) can bind 2019-nCoV S Protein RBD-SD1-mFc(Cat#BLPSN-0997P). The ED50 of Recombinant 2019-nCoV S Protein RBD-mFc(Cat#BLPSN-0997P) is 15.5 ng/ml .
formulation Recombinant Human ACE2 Protein is supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 300mM NaCl, 1mM ZnCl2, 10% Glycerol, pH 7.4.
stability The recombinant human ace2 protein is stable for up to 1 year from date of receipt at -20℃ to -80℃.
usage For Research Use Only
storage Store the ACE2 recombinant protein under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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