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Recombinant Human AAK1 Protein

Cat No.: BL-0002SG
Description
tag GST
host species Human
accession BC002695
synonym KIAA1048
background Adaptor-associated kinase 1 (AAK1) is a serine/threonine protein kinase of the NAK kinase. Along with GAK, AAK1 regulates clathrin-mediated endocytosis by phosphorylating the μ subunits of both AP-1 and AP-2 trafficking adaptors. The phosphorylation increases the affinity of AP2 for membranes and induces a conformational change enabling cargo recruitment by this adaptor. AAK1 was also shown to play a positive role in regulating the Notch pathway.
description Recombinant human AAK1 (1-465) was produced by baculovirus in Sf9 insect cells, fused with a GST tag at N-terminus. This protein is purified with our unique purification methods.
source Sf9 insect cells
AA sequence 1-465
molecular weight 78 kDa
purity For specific purity information on a given lot, see related COA.
endotoxin < 1.0 EU per μg of the protein as determined by the LAL method
bioactivity Active
formulation Recombinant protein is supplied in 50mM Tris-HCl, pH 7.5, 50mM NaCl, 10mM Glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF and 25% glycerol.
stability The recombinant protein is stable for up to 12 months at -70℃
usage For Research Use Only
storage Recombinant Human AAK1 Protein should be stored should be stored at < -70°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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