USA  Tel: 1-201-888-7983

Recombinant Cynomolgus HVEM Protein (Fc Tag)

Cat No.: BL-0026NP
Description Related products
tag Fc
host species Cynomolgus
accession XP_005545061.1
synonym HVEM Tumor Necrosis Factor Receptor Superfamily Member 14; Herpes Virus Entry Mediator A; Herpesvirus Entry Mediator A; HveA; Tumor Necrosis Factor Receptor-Like 2; TR2; CD270; TNFRSF14; HVEA; HVEM
background Herpesvirus entry mediator (HVEM) is a type I membrane protein in the TNF receptor superfamily, and it can both promote and inhibit T cell activity. HVEM is highly expressed on naïve CD4+ T cells, CD8+ T memory cells, regulatory T cells, dendritic cells, monocytes, and neutrophils. It functions as a receptor for BTLA, CD160, LIGHT/TNFSF14, and Lymphotoxin-alpha. Ligation of HVEM by LIGHT triggers T cell, monocyte, and neutrophil activation and contributes to Th1 inflammation and cardiac allograft rejection. In contrast, HVEM binding to CD160 or BTLA suppresses T cell and dendritic cell activation and dampens intestinal inflammation. HVEM enhances the development of CD8+ T cell memory and Treg function. It is additionally expressed on intestinal epithelial cells, where its binding by intraepithelial lymphocyte (IEL) expressed CD160 promotes epitheilal integrity and host defense. The herpesvirus envelope glycoprotein gD, which binds HVEM to initiate membrane fusion, can antagonize both BTLA and LIGHT binding.
description Recombinant Cynomolgus Herpesvirus entry mediator is expressed by our Mammalian expression system and the target gene encoding Pro37-Val203 is expressed with a Fc tag at the C-terminus.
source Human Cells
AA sequence Pro37-Val203
purity >95% as determined by reducing SDS-PAGE.
endotoxin <0.1 ng/µg (1 EU/µg) as determined by LAL test.
formulation Recombinant Cynomolgus HVEM Protein was lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.
reconstitution Dissolve the lyophilized protein in distilled water.
usage For Research Use Only
storage Cynomolgus HVEM protein should be stored at < -20°C, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7°C for 2-7 days.Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Online Inquiry
For quote, please fill in the online form or send email to
$50 Coupon