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Recombinant Cynomolgus CTLA-4 Protein (Fc Tag)

Cat No.: BL-0214NP
Description Related products
tag Fc
host species Cynomolgus
accession G7PL88
synonym CTLA-4 Cytotoxic T-lymphocyte protein 4; Cytotoxic T-lymphocyte-associated antigen 4; CTLA-4; CD152; CTLA4
background Cytotoxic Tlymphocyte 4(CTLA-4,CD152), is a type I transmembrane T cell inhibitory molecule that is a member of the Ig superfamily.CD28 and CTLA-4, together with their ligands, B7-1 and B7-2, constitute one of the dominant costimulatory pathways that regulate T and B cell responses. CD28 and CTLA-4 are structurally homologous molecules that are members of the immunoglobulin (Ig) gene superfamily. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T Cells and may play an important role in their functions. Tcell activation through the Tcell receptor and CD28 leads to increased expression of CTLA4.
description Recombinant Cynomolgus Cytotoxic T-lymphocyte associated protein 4 is expressed by our Mammalian expression system and the target gene encoding Ala37-Ser160 is expressed with a Fc tag at the C-terminus.
source Human Cells
AA sequence Ala37-Ser160
purity >95% as determined by reducing SDS-PAGE.
endotoxin <0.1 ng/µg (1 EU/µg) as determined by LAL test.
formulation Recombinant Cynomolgus CTLA-4 Protein was lyophilized from a 0.2 μm filtered solution of 50 mM Tris, 100 mM Glycine, pH7.5. .
reconstitution Dissolve the lyophilized protein in distilled water.
usage For Research Use Only
storage Cynomolgus CTLA-4 protein should be stored at < -20°C, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7°C for 2-7 days.Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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