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Recombinant 2019-nCoV S-trimer Protein (His Tag)

Cat No.: BLPSN-10018P
COVID-19 Spike protein, SARS-COV2 spike protein
Description Related products
tag His
host species 2019-nCoV
accession QHD43416.1
synonym 2019-nCov S protein; 2019-nCoV Spike glycoprotein; 2019-nCoV S glycoprotein, Spike glycoprotein of coronaviruse; 2019 novel coronavirus; COVID-2019; SARS-CoV-2; 2019-nCoV; CoV Spike protein; Recombinant COVID-19 Spike protein;
background Protein S (PROS1) is glycoprotein and expressed in many cell types supporting its reported involvement in multiple biological processes that include coagulation, apoptosis, cancer development and progression, and the innate immune response. Known receptors bind S1 are ACE2, angiotensin-converting enzyme 2, DPP4, CEACAM etc.. The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. Most notable is severe acute respiratory syndrome (SARS). The severe acute respiratory syndrome-coronavirus (SARS-CoV) spike (S) glycoprotein alone can mediate the membrane fusion required for virus entry and cell fusion. It is also a major immunogen and a target for entry inhibitors. It's been reported that 2019-nCoV can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.
description Recombinant SARS-CoV-2 / 2019-nCoV S-trimer Protein(aa 1-1208; GIAID#EPI_ISL_402121) is produced by our Mammalian expression system with a 6His tag at the C-terminus. Its furin cleavage site is removed. Majority are trimers.
source Human Cells
molecular weight 136.6kDa. AP Mol Mass: 170-220kDa, reducing conditions
purity >95% as determined by reducing SDS-PAGE.
formulation Recombinant 2019-nCoV S-trimer Protein was supplied as a 0.2 μM filtered solution of PBS,PH7.4.
applications Immunogen, calibrator or standard.
purification Affinity purification chromatography.
Sensitivity For Research Use Only
Detection Limit Store at < -20°C, stable for 12 months after receipt. Please Avoid repeated freeze-thaw cycles.
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