USA  Tel: 1-201-888-7983
Email: info@betalifesci.com

Recombinant 2019-nCoV Papain-Like Protease

Cat No.: BLPSN-10005P
Coronavirus 2019-nCoV Papain-Like Protease, COVID-19 Papain-Like Protease, SARS-COV2 Papain-Like Protease
Description Related products
tag N/A
host species 2019-nCoV
accession QHD43415.1
synonym Papain-like Protease; PLpro; PL-PRO; pp1a; Replicase polyprotein 1a
background Replication of severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV) requires proteolytic processing of the replicase polyprotein by two viral cysteine proteases, a chymotrypsin-like protease (3CLpro) and a papain-like protease (PLpro). These proteases are important targets for development of antiviral drugs that would inhibit viral replication and reduce mortality associated with outbreaks of SARS-CoV. PLpro is a cysteine protease located within the non-structural protein 3 (NS3) section of the viral polypeptide. PLPro activity is required to process the viral polyprotein into functional, mature subunits; specifically, PLPro cleaves a site at the amino-terminus of the viral replicase region. In addition to its role in viral protein maturation, PLPro possesses a deubiquitinating and deISGylating activity. In vivo, this protease antagonizes innate immunity by inhibiting IRF3-induced production of type I interferons.
description Recombinant 2019-nCoV Papain-like Protease is produced in E.coli and the target gene encoding Glu1564-Lys1878 is expressed.
source E.coli
AA sequence Glu1564-Lys1878
molecular weight 35.8kDa. AP Mol Mass: 34kDa, reducing conditions.
purity >90% as determined by reducing SDS-PAGE.
formulation Recombinant 2019-nCoV Papain-Like Protease was supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 10 mM Mercaptoethanol [BME], 20% Glycerol, pH 7.5.
Sensitivity For Research Use Only
Detection Limit Store at < -20°C, stable for 6 months after receipt. Please Avoid repeated freeze-thaw cycles.
Cat No. Product Name Source Detail Inquiry
BLPSN-10001P Recombinant 2019-nCoV NP CTD domain Protein (His Tag) E.coli
BLPSN-10002P Recombinant 2019-nCoV Spike Protein (RBD-SD1, His&Avi Tag) Human Cells 
BLSN-007M 2019-nCoV NP Monoclonal Antibody Human
BLPSN-10006P Recombinant 2019-nCoV NSP1 Protein (His Tag) E.coli
BLPSN-10007P Recombinant 2019-nCoV NSP2 Protein (His Tag) E.coli
BLPSN-10008P Recombinant 2019-nCoV NSP7 Protein (His Tag) E.coli
BLPSN-10009P Recombinant 2019-nCoV NSP8 Protein (His Tag) E.coli
BLPSN-10010P Recombinant 2019-nCoV NSP10 Protein (His Tag) E.coli
BLPSN-10011P Recombinant 2019-nCoV Guanine-N7 methyltransferase (His Tag) E.coli
BLPSN-10012P Recombinant 2019-nCoV Helicase (His Tag) E.coli
BLPSN-10013P Recombinant 2019-nCoV Spike Protein (RBD-SD1, His Tag) Human Cells
BLPSN-10014P Recombinant 2019-nCoV Spike Protein NTD (His Tag) Human Cells
BLPSN-10015P Recombinant 2019-nCoV Spike Protein CTD (His&Flag Tag) Human Cells
BLPSN-10016P Recombinant 2019-nCoV NP NTD domain (His Tag) E.coli
BLPSN-10017P Recombinant 2019-nCoV Spike Protein S2 (Fc Tag) Human Cells
BLSN-010P Rabbit Anti 2019-nCoV Nucleoprotein / NP Polyclonal Antibody Rabbit
BLSN-011M Mouse Anti 2019-nCoV Nucleoprotein / NP Monoclonal Antibody Mouse
BLA-0024P Recombinant Human coronavirus SARS CoV-2/2019-nCoV Nucleoprotein (His tag) E.coli
BLA-0025P Recombinant Human coronavirus SARS CoV-2/2019-nCoV Spike Glycoprotein S1 (Fc Tag) HEK293
BLA-0026P Recombinant Human coronavirus SARS CoV-2/2019-nCoV Spike Glycoprotein S2 (Fc Tag) HEK293
Online Inquiry
For quote, please fill in the online form or send email to info@betalifesci.com.
$50 Coupon