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Recombinant 2019-nCoV NSP8 Protein (His Tag)

Cat No.: BLPSN-10009P
Coronavirus SARS-COV2 NSP8, COVID-19 NSP8
Description Related products
tag His
host species 2019-nCoV
accession YP_009725304.1
synonym SARS-CoV 2 nsp8; COVID-19 NSP8
background Cleavage by the viral main protease, 3CLpro results in generating the nsp8 protein, The nsp8 protein has been shown to associate with several other nsps and to colocalize with these nsps in cytoplasmic complexes that are important for viral RNA synthesis. It forms a hexadecamer with nsp7 (8 subunits of each) that may participate in viral replication by acting as a primase. Alternatively, may synthesize substantially longer products than oligonucleotide primers. Nsp8 was shown to have RNA-dependent RNA polymerase (RdRp) activity that could be involved in producing primers utilized by nsp12 which is normally accepted to be the RdRp for SARS-CoV.
description Recombinant 2019-nCoV NSP8 is produced by our E.coli expression system and the target gene encoding Ala1-Gln198 is expressed with a 6His tag at the C-terminus.
source E.coli
AA sequence Ala1-Gln198
molecular weight 25kDa. AP Mol Mass: 25kDa, reducing conditions.
purity >85% as determined by reducing SDS-PAGE.
formulation Recombinant 2019-nCoV NSP8 was supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, 10% Glycerol, pH 8.5.
Sensitivity For Research Use Only
Detection Limit Store at < -20°C, stable for 6 months after receipt. Please Avoid repeated freeze-thaw cycles.
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