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Recombinant 2019-nCoV NSP1 Protein (His Tag)

Cat No.: BLPSN-10006P
Coronavirus SARS-COV2 NSP1, COVID-19 NSP1
Description Related products
tag His
host species 2019-nCoV
accession YP_009725297.1
synonym SARS-CoV 2 nsp1; SARS-CoV 2 Leader protein
background The Severe Acute Respiratory Syndrome (SARS) Coronavirus (CoV) is an enveloped, positive-stranded RNA viruses that can cause a severe respiratory disease. Its genome consists of a ∼30 kb linear, non-segmented, capped, polycistronic, polyadenylated RNA molecule, the first two-third of which is directly translated into two large polyproteins. These two polypeptides are processed into 16 non-structural proteins (nsps), forming the replicase complex, which is active in the cytoplasm in close association with cellular membranes. Nsp1 was proved to be able to suppress host gene expression by promoting host mRNA degradation and was involved in cellular chemokine deregulation. This virus evades the host innate immune response in part through the expression of its non-structural protein (nsp) 1, which inhibits both host gene expression and virus- and interferon (IFN)-dependent signaling. Thus, nsp1 is a promising target for drugs, as inhibition of nsp1 would make SARS-CoV more susceptible to the host antiviral defenses.
description Recombinant 2019-nCoV NSP1 is produced in E.coli and the target gene encoding Met1-Gly180 is expressed with a 6His tag at the C-terminus.
source E.coli
AA sequence Met1-Gly180
molecular weight 22.7kD. AP Mol Mass: 25kDa, reducing conditions.
purity >85% as determined by reducing SDS-PAGE.
formulation Recombinant 2019-nCoV NSP1 was supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, 10% Glycerol, pH 8.5.
Sensitivity For Research Use Only
Detection Limit Store at < -20°C, stable for 6 months after receipt. Please Avoid repeated freeze-thaw cycles.
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