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Recombinant 2019-nCoV Guanine-N7 methyltransferase (His Tag)

Cat No.: BLPSN-10011P
Coronavirus sars-cov2 Guanine-N7_meth, COVID-19 Guanine-N7_meth
Description Related products
tag His
host species 2019-nCoV
accession YP_009725309.1
synonym SARS-CoV 2 nsp14; SARS-CoV 2 ExoN; Guanine-N7 methyltransferase
background The nonstructural protein (nsp) 14 of SARS-CoV 2 was identified as a cap (guanine-N7)-methyltransferase (N7-MTase). Nsp14 of coronaviruses two different activities: an exoribonuclease activity acting on both ssRNA and dsRNA in a 3' to 5' direction and a N7-guanine methyltransferase activity. It may be involved in the proof-reading ability during the viral RNA replication and transcription. GTP, dGTP as well as cap analogs GpppG, GpppA and m7GpppG could be methylated by nsp14.positive-stranded RNA genome of the coronaviruses is translated from ORF1 to yield polyproteins that are proteolytically processed into intermediate and mature nonstructural proteins (nsps). SARS-CoV 2 polyproteins incorporate 16 protein domains (nsps). The putative non-structural protein 2 (nsp2) of SARS-CoV plays an important role in viral transcription and replication, and is an attractive target for anti-SARS drug development.
description Recombinant 2019-nCoV Guanine-N7 methyltransferase is produced by our E.coli expression system and the target gene encoding Ala1-Gln527 is expressed with a 6His tag at the N-terminus.
source E.coli
AA sequence Ala1-Gln527
molecular weight 62.9kDa. AP Mol Mass: 60kDa, reducing conditions.
purity >85% as determined by reducing SDS-PAGE.
formulation Recombinant 2019-nCoV Guanine-N7 methyltransferase was Supplied as a 0.2 μm filtered solution of PBS, 10% Glycerol, pH 7.4.
Sensitivity For Research Use Only
Detection Limit Store at < -20°C, stable for 6 months after receipt. Please Avoid repeated freeze-thaw cycles.
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