Recombinant Rhesus EGFR Protein (ECD, Fc Tag)

Beta LifeScience SKU/CAT #: BLPSN-1739
Recombinant Rhesus EGFR Protein (ECD, Fc Tag)

Recombinant Rhesus EGFR Protein (ECD, Fc Tag)

Beta LifeScience SKU/CAT #: BLPSN-1739
Catalog No.: BLPSN-1739

Product Overview

Tag Fc
Host Species Rhesus
Accession XP_001107305.1
Background As a member of the epidermal growth factor receptor (EGFR) family, EGFR protein is type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF, amphiregulin, TGF-alpha, betacellulin, etc. EGFR protein plays a crucial role in signaling pathway in the regulation of cell proliferation, survival and differentiation. Binding of a ligand induces EGFR protein homo- or heterodimerization, the subsequent tyrosine autophosphorylation and initiates various down stream pathways (MAPK, PI3K/PKB and STAT). In addition, EGFR signaling also has been shown to exert action on carcinogenesis and disease progression, and thus EGFR protein is proposed as a target for cancer therapy currently.Immune CheckpointImmunotherapyCancer ImmunotherapyTargeted Therapy
Description A DNA sequence encoding the rhesus EGFR (XP_001107305.1) (Met1-Ser645) was expressed with the Fc region of human IgG1 at the C-terminus.
Source HEK293
Predicted N Terminal Leu 25
AA Sequence Met1-Ser645
Molecular Weight The recombinant rhesus EGFR consists 859 a.a. and predicts a molecular mass of 95.4 kDa.
Purity >95% as determined by SDS-PAGE
Endotoxin < 1.0 EU per μg protein as determined by the LAL method.
Bioactivity Please contact us for detailed information
Formulation Lyophilized from sterile PBS, pH 7.4..
Stability The recombinant proteins are stable for up to 1 year from date of receipt at -70°C.
Usage For Research Use Only
Storage Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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