Recombinant Rhesus DC-SIGN Protein (His Tag)

Beta LifeScience SKU/CAT #: BLPSN-1560
Recombinant Rhesus DC-SIGN Protein (His Tag)

Recombinant Rhesus DC-SIGN Protein (His Tag)

Beta LifeScience SKU/CAT #: BLPSN-1560
Catalog No.: BLPSN-1560

Product Overview

Tag His
Host Species Rhesus
Accession AAK74185.1
Synonym CD209, DC-SIGN
Background Dendritic cell (DC)-specific intercellular adhesion molecule 3 (ICAM-3) grabbing nonintegrin (DC-SIGN), also known as CD29, is a type II transmembrane protein on DCs with a C-type lectin extracellular domain, is capable of binding ICAM-3 on resting T cells in the secondary lymphoid organs, providing the initial contact between these cells during the establishment of cell-mediated immunity. It is not only a pattern recognition receptor but implicated in immunoregulation of DCs. It has important role in mediating DC adhesion, migration, inflammation, activating primary T cell, triggering immune response and participating in immune escape of pathogens and tumors. DC-SIGN also mediates capture and internalization of viral, bacterial, and fungal pathogens by dendritic cells, such as HIV-1, Ebola virus, cytomegalovirus, Dengue virus, and hepatitis C virus. DC-SIGN is unique in that it regulates adhesion processes, such as DC trafficking and T-cell synapse formation, as well as antigen capture. Moreover, even though several C-type lectins have been shown to bind HIV-1, DC-SIGN does not only capture HIV-1 but also protects it in early endosomes allowing HIV-1 transport by DC to lymphoid tissues, where it enhances trans infection of T cells.Immune CheckpointImmunotherapyCancer ImmunotherapyTargeted Therapy
Description A DNA sequence encoding the rhesus CD209 (AAK74185.1) (Lys62-Glu381) was expressed with a His tag at the N-terminus.
Source HEK293
Predicted N Terminal His
AA Sequence Lys62-Glu381
Molecular Weight The recombinant rhesus CD209 consists of 339 a.a. and predicts a molecular mass of 38.8 kDa.
Purity >95% as determined by SDS-PAGE.
Endotoxin < 1.0 EU per μg protein as determined by the LAL method.
Bioactivity Please contact us for detailed information
Formulation Lyophilized from sterile PBS, pH 7.4..
Stability The recombinant proteins are stable for up to 1 year from date of receipt at -70°C.
Usage For Research Use Only
Storage Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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