Recombinant Rat VE-Cadherin Protein (Fc Tag)
Beta LifeScience
SKU/CAT #: BLPSN-4769
Recombinant Rat VE-Cadherin Protein (Fc Tag)
Beta LifeScience
SKU/CAT #: BLPSN-4769
Catalog No.: BLPSN-4769
Product Overview
| Tag | Fc |
| Host Species | Rat |
| Accession | NP_001100877.1 |
| Background | Cadherins (Calcium dependent adhesion molecules) are a class of transmembrane proteins. Cadherin-5, also known as VE-cadherin, CDH5 and CD144, an endothelial specific cell-cell adhesion molecule, plays a pivotal role in the formation, maturation and remodeling of the vascular wall. VE-Cadherin is widely considered to be specific for vascular endothelia in which it is either the sole or the predominant cadherin, often co-existing with N-cadherin. This specificity of VE-cadherin for vascular endothelial cells is important not only in blood and lymph vessel biology and medicine, but also for cell-type-based diagnoses, notably those of metastatic tumors. As a classical cadherin, VE-Cadherin links endothelial cells together by homophilic interactions mediated by its extracellular part and associates intracellularly with the actin cytoskeleton via catenins. Mechanisms that regulate VE-cadherin-mediated adhesion are important for the control of vascular permeability and leukocyte extravasation. In addition to its adhesive functions, VE-Cadherin regulates various cellular processes such as cell proliferation and apoptosis and modulates vascular endothelial growth factor receptor functions. Consequently, VE-cadherin is essential during embryonic angiogenesis. |
| Description | A DNA sequence encoding the rat CDH5 (NP_001100877.1) (Met1-Gln585) was expressed with a His tag at the C-terminus. |
| Source | HEK293 |
| Predicted N Terminal | Gly 25 |
| AA Sequence | Met1-Gln585 |
| Molecular Weight | The recombinant rat CDH5 comprises 802 a.a. and predicts a molecular mass of 90.7 kDa. The apparent molecular mass of the recombinant protein is approximately 116 kDa in SDS-PAGE under reducing conditions due to glycosylation. |
| Purity | >75% as determined by SDS-PAGE |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method |
| Bioactivity | Please contact us for detailed information |
| Formulation | Lyophilized from sterile PBS, pH 7.4. |
| Stability | The recombinant proteins are stable for up to 1 year from date of receipt at -70°C. |
| Usage | For Research Use Only |
| Storage | Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
