Recombinant Rat VE-Cadherin Protein (Fc Tag)

Beta LifeScience SKU/CAT #: BLPSN-4769
Recombinant Rat VE-Cadherin Protein (Fc Tag)

Recombinant Rat VE-Cadherin Protein (Fc Tag)

Beta LifeScience SKU/CAT #: BLPSN-4769
Catalog No.: BLPSN-4769

Product Overview

Tag Fc
Host Species Rat
Accession NP_001100877.1
Background Cadherins (Calcium dependent adhesion molecules) are a class of transmembrane proteins. Cadherin-5, also known as VE-cadherin, CDH5 and CD144, an endothelial specific cell-cell adhesion molecule, plays a pivotal role in the formation, maturation and remodeling of the vascular wall. VE-Cadherin is widely considered to be specific for vascular endothelia in which it is either the sole or the predominant cadherin, often co-existing with N-cadherin. This specificity of VE-cadherin for vascular endothelial cells is important not only in blood and lymph vessel biology and medicine, but also for cell-type-based diagnoses, notably those of metastatic tumors. As a classical cadherin, VE-Cadherin links endothelial cells together by homophilic interactions mediated by its extracellular part and associates intracellularly with the actin cytoskeleton via catenins. Mechanisms that regulate VE-cadherin-mediated adhesion are important for the control of vascular permeability and leukocyte extravasation. In addition to its adhesive functions, VE-Cadherin regulates various cellular processes such as cell proliferation and apoptosis and modulates vascular endothelial growth factor receptor functions. Consequently, VE-cadherin is essential during embryonic angiogenesis.
Description A DNA sequence encoding the rat CDH5 (NP_001100877.1) (Met1-Gln585) was expressed with a His tag at the C-terminus.
Source HEK293
Predicted N Terminal Gly 25
AA Sequence Met1-Gln585
Molecular Weight The recombinant rat CDH5 comprises 802 a.a. and predicts a molecular mass of 90.7 kDa. The apparent molecular mass of the recombinant protein is approximately 116 kDa in SDS-PAGE under reducing conditions due to glycosylation.
Purity >75% as determined by SDS-PAGE
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method
Bioactivity Please contact us for detailed information
Formulation Lyophilized from sterile PBS, pH 7.4.
Stability The recombinant proteins are stable for up to 1 year from date of receipt at -70°C.
Usage For Research Use Only
Storage Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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