Recombinant Rat GRO beta / CXCL2 Protein
Beta LifeScience
SKU/CAT #: BLPSN-2336
Recombinant Rat GRO beta / CXCL2 Protein
Beta LifeScience
SKU/CAT #: BLPSN-2336
Catalog No.: BLPSN-2336
Product Overview
| Tag | N/A |
| Host Species | Rat |
| Accession | NP_446099.1 |
| Background | Chemokine (C-X-C motif) ligand 2 (CXCL2), also called macrophage inflammatory protein 2 (MIP-2), Growth-regulated protein beta (Gro-beta) and Gro oncogene-2 (Gro-2), is a small cytokine belonging to the CXC chemokine family. CXCL2/MIP-2 is selectively up-regulated in tolerance-conferring APCs and serves to recruit NKT cells to the splenic marginal zone, where they form clusters with APCs and T cells. In the absence of the high-affinity receptor for CXCL2/MIP-2 or in the presence of a blocking Ab to CXCL2/MIP-2, peripheral tolerance is prevented, and Ag-specific T regulatory cells are not generated. CXCL2/MIP-2 is selectively up-regulated in tolerance-conferring APCs and serves to recruit NKT cells to the splenic marginal zone, where they form clusters with APCs and T cells. In the absence of the high-affinity receptor for MIP-2 (as in CXCR2-deficient mice) or in the presence of a blocking Ab to MIP-2, peripheral tolerance is prevented, and Ag-specific T regulatory cells are not generated. Understanding the regulation of lymphocyte traffic during tolerance induction may lead to novel therapies for autoimmunity, graft acceptance, and tumor rejection. Several studies have implicated the CXCL2 chemokine as a mediator in the development of sepsis. CXCL2/MIP-2 also plays a major role in mediating the neutrophilic inflammatory response of the rodent lung to particles such as quartz, crocidolite asbestos, as well as high doses of other relative innocuous dusts such as titanium dioxide. |
| Description | A DNA sequence encoding the rat Cxcl2 (NP_446099.1) (Ser32-Asn100) was expressed with two additional amino acids (Gly & Pro ) at the N-terminus. |
| Source | E.coli |
| Predicted N Terminal | Ser 69 |
| AA Sequence | Ser32-Asn100 |
| Molecular Weight | The recombinant rat Cxcl2 consists 69 a.a. and predicts a molecular mass of 7.6 kDa. |
| Purity | >85% as determined by SDS-PAGE. |
| Endotoxin | Please contact us for more information. |
| Bioactivity | Please contact us for detailed information |
| Formulation | Lyophilized from sterile 20 mM Tris, 500 mM NaCl, pH 8.. |
| Stability | The recombinant proteins are stable for up to 1 year from date of receipt at -70°C. |
| Usage | For Research Use Only |
| Storage | Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
