Recombinant Rat CLEC14A Protein (Fc Tag)
Beta LifeScience
SKU/CAT #: BLPSN-1300
Recombinant Rat CLEC14A Protein (Fc Tag)
Beta LifeScience
SKU/CAT #: BLPSN-1300
Catalog No.: BLPSN-1300
Product Overview
| Tag | Fc |
| Host Species | Rat |
| Accession | NP_001014099.1 |
| Background | C-type lectin domain family 14 member A, also known as Epidermal growth factor receptor 5 and CLEC14A, is a member of the C-type lectin domain (CTLD) family that contains one c-type lectin domain and one EGF-like domain. Mouse CLEC14A is a 459 amino acid single-pass type I membrane protein. The superfamily of proteins containing C-type lectin-like domains (CTLDs) is a large group of extracellular Metazoan proteins with diverse functions. The CTLD structure has a characteristic double-loop ('loop-in-a-loop') stabilized by two highly conserved disulfide bridges located at the bases of the loops, as well as a set of conserved hydrophobic and polar interactions. Members of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily share a common fold and are involved in a variety of functions, such as generalized defense mechanisms against foreign agents, discrimination between healthy and pathogen-infected cells, and endocytosis and blood coagulation. Genome-level studies on human, elegans and melanogaster demonstrated almost complete divergence among invertebrate and mammalian families of CTLD-containing proteins (CTLDcps). The vertebrate CTLDcp families were essentially formed early in vertebrate evolution and are completely different from the invertebrate families. The composition of the CTLDcp superfamily in fish and mammals suggests that large scale duplication events played an important role in the evolution of vertebrates. |
| Description | A DNA sequence encoding the rat CLEC14A (Met1-Thr398) was expressed with the Fc region of human IgG1 at the C-terminus. |
| Source | HEK293 |
| Predicted N Terminal | Glu 22 |
| AA Sequence | Met1-Thr398 |
| Molecular Weight | The recombinant rat CLEC14A/Fc is a disulfide-linked homodimer. The reduced monomer comprises 618 a.a. and has a predicted molecular mass of 67.6 kDa. The apparent molecular mass of the protein is approximately 110 and 37 kDa in SDS-PAGE under reducing conditions. |
| Purity | (75.4+12.7)% as determined by SDS-PAGE |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method |
| Bioactivity | Please contact us for detailed information |
| Formulation | Lyophilized from sterile PBS, pH 7.4. |
| Stability | The recombinant proteins are stable for up to 1 year from date of receipt at -70°C. |
| Usage | For Research Use Only |
| Storage | Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
