Recombinant Rat B2M Protein (His Tag)

Beta LifeScience SKU/CAT #: BLPSN-0393
Recombinant Rat B2M Protein (His Tag)

Recombinant Rat B2M Protein (His Tag)

Beta LifeScience SKU/CAT #: BLPSN-0393
Catalog No.: BLPSN-0393

Product Overview

Tag His
Host Species Rat
Accession P07151
Background B2M, also known as beta2-Microglobulin or CDABP92, is a component of MHC class I molecules found expression in all nucleated cells (excludes red blood cells). The major function of MHC class I moleculesis is to display fragments of proteins from within the cell to T-cells and cells containing foreign proteins will be attacked. B2M(beta2-Microglobulin) is a low molecular weight protein. It was demonstrated that B2M(beta2-Microglobulin) was localized in the membranes of nucleated cells and was found to be associated with HL-A antigens.B2M(beta2- Microglobulin) is present in free form in various body fluids and as a subunit of histocompatibility antigens on cell surfaces lateral to thealpha3 chain. Unlikealpha3, beta2 has no transmembrane region. Directly above beta2 lies the alpha1 chain, which itself is lateral to the alpha2. In the absence of B2M(beta2 microglobulin), very limited amounts of MHC class I (classical and non-classical) molecules can be detected on the surface. In the absence of MHC class I, CD8 T cells, a subset of T cells involved in the development of acquired immunity cannot develop. Low levels of B2M(beta2 microglobulin) can indicate non-progression of HIV.
Description A DNA sequence encoding the rat B2M (P07151) (Met 1-Met 119) was expressed, fused with a His tag at the C-terminus.
Source HEK293
Predicted N Terminal Ile 21
AA Sequence Met 1-Met 119
Molecular Weight The secreted recombinant rat B2M comprises 110 a.a. and predicts a molecular mass of 13 kDa. The apparent molecular mass of the rat B2M is approximately 15 kDa in SDS-PAGE under reducing conditions.
Purity >97% as determined by SDS-PAGE
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method
Bioactivity Please contact us for detailed information
Formulation Lyophilized from sterile PBS, pH 7.4.
Stability The recombinant proteins are stable for up to 1 year from date of receipt at -70°C.
Usage For Research Use Only
Storage Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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