Name: Recombinant Mouse TROY Protein (His Tag)
Brand: Beta LifeScience
SKU: BLPSN-4682
Availability: InStock

Recombinant Mouse TROY Protein (His Tag)

Catalog No.: BLPSN-4682

Product Overview

Tag	His
Host Species	Mouse
Accession	NP_001157627.1
Synonym	AL023044, AW123854, TAJ, TAJ-ALPHA, TRADE, Troy
Background	Tumor necrosis factor receptor superfamily, member 19 (TNFRSF19), also known as TAJ-alpha or TROY, is a member of the TNF-receptor superfamily. TNFRSF19/TROY expression is detected in the pulmonary epithelium and the ductal epithelium of the prostate and parotid glands. TNFRSF19/TROY expression is detected in some adenocarcinoma cell lines that arise from this tissue. It has been shown to interact with TRAF family members, and to activate JNK signaling pathway when overexpressed in cells. TNFRSF19/TROY is capable of inducing apoptosis by a caspase-independent mechanism, and it is thought to play an essential role in embryonic development. TNFRSF19/TROY was negatively regulated by adipogenic transcription factor CCAAT/enhancer-binding proteins (C/EBP). TNFRSF19 signals activation of the Jnk pathway and induces cell death. Overexpression of TNFRSF19 also signals NFB activation, comparable and similar to that by p75NGFR. TNFRSF19/TROY is capable of activating key signaling pathways of the TNF receptor family, and its predominant expression patterns suggest that it plays a role in the growth and regulation of epithelial tissues.
Description	A DNA sequence encoding the extracellular domain (Met 1-Leu 170) of mouse TNFRSF19 (NP_001157627.1) was fused with a His tag at the C-terminus.
Source	HEK293
Predicted N Terminal	Glu 30
AA Sequence	Met 1-Leu 170
Molecular Weight	The recombinant mouse TNFRSF19 consists of 152 a.a. and has a predicted molecular mass of 17 kDa. Due to glycosylation, the apparent molecular mass of rmTNFRSF19 is approximately 25-32 kDa in SDS-PAGE under reducing conditions.
Purity	>95% as determined by SDS-PAGE
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Bioactivity	Please contact us for detailed information
Formulation	Lyophilized from sterile PBS, pH 7.4.
Stability	The recombinant proteins are stable for up to 1 year from date of receipt at -70°C.
Usage	For Research Use Only
Storage	Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.