Name: Recombinant Mouse HAI-2 Protein (His Tag)
Brand: Beta LifeScience
SKU: BLPSN-2366
Availability: InStock

Recombinant Mouse HAI-2 Protein (His Tag)

Catalog No.: BLPSN-2366

Product Overview

Tag	His
Host Species	Mouse
Accession	NP_001076017.1
Synonym	AL024025, C76321, HAI-2
Background	Choanal (CA) and gastrointestinal atresias (GA) are an important feature of syndromic congenital sodium diarrhea (sCSD), a disorder recently associated with mutations in the gene for serine protease inhibitor type 2 (SPINT2). The SPINT2 gene is epigenetically silenced or downregulated in human cancers, altering the balance of HGF activation/inhibition ratio, which contributes to cancer development and progression. SPINT2 is a tumor suppressor gene that inhibits proteases implicated in cancer progression, like HGFA, hepsin and matriptase. Loss of SPINT2 expression in tumors has been associated with gene promoter hypermethylation. SPINT2 (serine peptidase inhibitor Kunitz type 2), a proteolytic inhibitor of hepatocyte growth factor activator (HGFA), which has a significant role in the suppression of the HGF-MET pathway and malignant melanoma progression.
Description	A DNA sequence encoding the extracellular domain (Met 1-Lys 140) of mouse SPINT2 (NP_001076017.1) precursor was expressed with a C-terminal His tag.
Source	HEK293
Predicted N Terminal	Glu 31
AA Sequence	Met 1-Lys 140
Molecular Weight	The secreted recombinant mouse SPINT2 consists of 122 a.a. and has a calculated molecular mass of 14 kDa. As a result of glycosylation, the recombinant protein migrates as an approximately 22 kDa protein in SDS-PAGE under reducing conditions.
Purity	>90% as determined by SDS-PAGE
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Bioactivity	Please contact us for detailed information
Formulation	Lyophilized from sterile PBS, pH 7.4.
Stability	The recombinant proteins are stable for up to 1 year from date of receipt at -70°C.
Usage	For Research Use Only
Storage	Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.