Recombinant Mouse FSTL1 Protein (His Tag)
Beta LifeScience
SKU/CAT #: BLPSN-2159
Recombinant Mouse FSTL1 Protein (His Tag)
Beta LifeScience
SKU/CAT #: BLPSN-2159
Catalog No.: BLPSN-2159
Product Overview
| Tag | His |
| Host Species | Mouse |
| Accession | NP_032073.2 |
| Synonym | AI316791, AW107808, Fstl, TSC-36 |
| Background | Follistatin-related protein 1 (FSTL1) is an extracellular glycoprotein whose functional significance in physiological and pathological processes is incompletely understood. Recently, we have shown that FSTL1 acts as a muscle-derived secreted factor that is up-regulated by Akt activation and ischemic stress and that FSTL1 exerts favorable actions on the heart and vasculature. Here, we sought to identify the receptor that mediates the cellular actions of FSTL1. It contains an FS module, a follistatin-like sequence containing 1 conserved cysteine residues. FSTL1 is thought to be an autoantigen associated with rheumatoid arthritis. DIP2A functions as a novel receptor that mediates the cardiovascular protective effects of FSTL1. Experiment results have provided in vivo and in vitro evidence to demonstrate that Fstl1 modulates lung development and alveolar maturation, in part, through BMP4 signaling. |
| Description | A DNA sequence encoding the mouse FSTL1 (NP_032073.2) (Met1-Ile306) was expressed with a C-terminal His tag. |
| Source | HEK293 |
| Predicted N Terminal | Glu 19 |
| AA Sequence | Met1-Ile306 |
| Molecular Weight | The recombinant mouse FSTL1 comprises 299 a.a. and has a predicted molecular mass of 33.9 kDa. The apparent molecular mass of the protein is approximately 44.9 kDa in SDS-PAGE under reducing conditions. |
| Purity | >95% as determined by SDS-PAGE |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method |
| Bioactivity | Please contact us for detailed information |
| Formulation | Lyophilized from sterile PBS, pH 7.4.. |
| Stability | The recombinant proteins are stable for up to 1 year from date of receipt at -70°C. |
| Usage | For Research Use Only |
| Storage | Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
