Recombinant Mouse FDPS Protein (His Tag)
Beta LifeScience
SKU/CAT #: BLPSN-2021
Recombinant Mouse FDPS Protein (His Tag)
Beta LifeScience
SKU/CAT #: BLPSN-2021
Catalog No.: BLPSN-2021
Product Overview
| Tag | His |
| Host Species | Mouse |
| Accession | NP_608219.1 |
| Synonym | 6030492I17Rik, AI256750, Fdpsl1, mKIAA1293 |
| Background | Z-farnesyl diphosphate synthase (FDPS) is an enzyme belonging to the family of transferases, specifically those transferring aryl or alkyl groups other than methyl groups. Z-farnesyl diphosphate synthase (FDPS) functions as key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate, a precurcor for several classes of essential metabolites. FDPS catalyzes the production of geranyl pyrophosphate and farnesyl pyrophosphate from isopentenyl pyrophosphate and dimethylallyl pyrophosphate. The resulting product, farnesyl pyrophosphate, is a key intermediate in cholesterol and sterol biosynthesis, a substrate for protein farnesylation and geranylgeranylation, and a ligand or agonist for certain hormone receptors and growth receptors. Drugs that inhibit this enzyme prevent the post-translational modifications of small GTPases and have been used to treat diseases related to bone resorption. Functions of FDPS may be inactivated by interferon-induced RSAD2. This inactivation may result of disruption of lipid rafts at the plasma membrane, and thus have an antiviral effect since many enveloped viruses need lipid rafts to bud efficiently out of the cell. |
| Description | A DNA sequence encoding the mouse Fdps (NP_608219.1) (Met1-Lys353) was expressed with a His tag at the N-terminus. |
| Source | E.coli |
| Predicted N Terminal | Met |
| AA Sequence | Met1-Lys353 |
| Molecular Weight | The recombinant mouse Fdps consists 371 a.a. and predicts a molecular mass of 42.8 kDa. |
| Purity | >85% as determined by SDS-PAGE. |
| Endotoxin | Please contact us for more information. |
| Bioactivity | Please contact us for detailed information |
| Formulation | Lyophilized from sterile 50 mM Tris, pH 8.0.. |
| Stability | The recombinant proteins are stable for up to 1 year from date of receipt at -70°C. |
| Usage | For Research Use Only |
| Storage | Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
