Recombinant Mouse FDPS Protein (His Tag)

Beta LifeScience SKU/CAT #: BLPSN-2021
Recombinant Mouse FDPS Protein (His Tag)

Recombinant Mouse FDPS Protein (His Tag)

Beta LifeScience SKU/CAT #: BLPSN-2021
Catalog No.: BLPSN-2021

Product Overview

Tag His
Host Species Mouse
Accession NP_608219.1
Synonym 6030492I17Rik, AI256750, Fdpsl1, mKIAA1293
Background Z-farnesyl diphosphate synthase (FDPS) is an enzyme belonging to the family of transferases, specifically those transferring aryl or alkyl groups other than methyl groups. Z-farnesyl diphosphate synthase (FDPS) functions as key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate, a precurcor for several classes of essential metabolites. FDPS catalyzes the production of geranyl pyrophosphate and farnesyl pyrophosphate from isopentenyl pyrophosphate and dimethylallyl pyrophosphate. The resulting product, farnesyl pyrophosphate, is a key intermediate in cholesterol and sterol biosynthesis, a substrate for protein farnesylation and geranylgeranylation, and a ligand or agonist for certain hormone receptors and growth receptors. Drugs that inhibit this enzyme prevent the post-translational modifications of small GTPases and have been used to treat diseases related to bone resorption. Functions of FDPS may be inactivated by interferon-induced RSAD2. This inactivation may result of disruption of lipid rafts at the plasma membrane, and thus have an antiviral effect since many enveloped viruses need lipid rafts to bud efficiently out of the cell.
Description A DNA sequence encoding the mouse Fdps (NP_608219.1) (Met1-Lys353) was expressed with a His tag at the N-terminus.
Source E.coli
Predicted N Terminal Met
AA Sequence Met1-Lys353
Molecular Weight The recombinant mouse Fdps consists 371 a.a. and predicts a molecular mass of 42.8 kDa.
Purity >85% as determined by SDS-PAGE.
Endotoxin Please contact us for more information.
Bioactivity Please contact us for detailed information
Formulation Lyophilized from sterile 50 mM Tris, pH 8.0..
Stability The recombinant proteins are stable for up to 1 year from date of receipt at -70°C.
Usage For Research Use Only
Storage Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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